Τίτλος:
Evaluation of metastases to the pancreas with fine needle aspiration: A case series from a single centre with review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Fine needle aspiration (FNA) is a minimally invasive albeit highly effective modality used to detect solid and cystic pancreatic lesions. This manuscript aims to present our experience in diagnosing metastases to the pancreas and highlight the importance of immunocytochemistry in the diagnostic process. It also aims to provide a brief review of the literature on this topic. Methods: We retrospectively searched our archives for cases of metastatic deposits to the pancreas diagnosed with FNA over a 5-year period. We also reviewed the literature for such cases. Results: We describe seven cases from our archives that metastasised to the pancreas. Three of them (43%) represented metastatic renal cell carcinoma while the rest four comprised deposits from a lung adenocarcinoma, a colon adenocarcinoma, an adrenal leiomyosarcoma, and a small cell carcinoma of the urinary bladder, respectively. History of primary malignancy was available for all seven patients. All diagnoses were confirmed with the use of immunostains. In our literature review, similar to our case series, renal cell carcinoma was the most common metastasis to the pancreas managed with FNA (around one out of three patients; 35%). Of interest, our endoscopic ultrasound-FNA case of pancreatic metastasis from urinary bladder small cell carcinoma is the first reported. Conclusions: As metastases to the pancreas are commonly accompanied by diverse prognostic signatures and management strategies compared to primary pancreatic malignancies, their accurate identification is imperative. Pancreatic FNA is a diagnostic modality that can confirm or exclude metastasis to the organ, especially when immunocytochemistry is applied. © 2020 John Wiley & Sons Ltd
Συγγραφείς:
Ioakim, K.J.
Sydney, G.I.
Michaelides, C.
Sepsa, A.
Psarras, K.
Tsiotos, G.G.
Salla, C.
Nikas, I.P.
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
caldesmon; CD56 antigen; chromogranin; common acute lymphoblastic leukemia antigen; cytokeratin 20; cytokeratin 7; desmin; epithelial membrane antigen; homeobox protein Nkx 2.1; smooth muscle actin; synaptophysin; transcription factor Cdx2; transcription factor PAX8; vimentin, adult; aged; angiosarcoma; Article; bladder carcinoma; breast carcinoma; chondrosarcoma; clinical article; colon adenocarcinoma; colon carcinoma; computer assisted tomography; differential diagnosis; endoscopic ultrasonography; female; fine needle aspiration biopsy; gastrointestinal stromal tumor; human; immunochemistry; immunocytochemistry; immunohistochemistry; kidney metastasis; large cell neuroendocrine carcinoma; leiomyosarcoma; liposarcoma; lung adenocarcinoma; lung carcinoma; male; malignant fibrous histiocytoma; malignant peripheral nerve sheath tumor; melanoma; merkel cell carcinoma; middle aged; mixed adenoneuroendocrine carcinoma; neuroblastoma; neuroendocrine carcinoma; neuroendocrine tumor; osteosarcoma; pancreas islet cell tumor; pancreas metastasis; phyllodes tumor; primary tumor; priority journal; renal cell carcinoma; retrospective study; rhabdomyosarcoma; small cell carcinoma; small cell lung cancer; solitary fibrous tumor; synovial sarcoma; thyroid medullary carcinoma; colon tumor; endoscopic ultrasound guided fine needle biopsy; fine needle aspiration biopsy; leiomyoma; lung adenocarcinoma; metastasis; pancreas tumor; pathology; procedures; prognosis; renal cell carcinoma, Adenocarcinoma of Lung; Aged; Biopsy, Fine-Needle; Carcinoma, Renal Cell; Colonic Neoplasms; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Female; Humans; Immunohistochemistry; Leiomyoma; Male; Middle Aged; Neoplasm Metastasis; Pancreatic Neoplasms; Prognosis
