Τίτλος:
Differential diagnosis of behavioral variant and semantic variant of frontotemporal dementia using visual rating scales
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Frontotemporal dementia (FTD) represents the second most frequent early onset of dementia in people younger than 65 years. The main syndromes encompassed by the term FTD are behavioral variant of Frontotemporal dementia (bvFTD), non-fluent variant primary progressive aphasia (nfvPPA) and semantic variant (SD). Aims: To assess the bvFTD and SD, which represent the most common subtypes of FTD, using visual rating scales. Methods: Brain MRI exams of 77 patients either with bvFTD (n=43) or SD (n=34) were evaluated. The rating scales used were: Global cortical atrophy (GCA), Fazekas Scale: periventricular (PV) and white matter (WM) changes, Koedam rating scale and visual scales regarding specific cortical regions: dorsofrontal (DF), orbitofrontal (OF), anterior cingulate (AC), basal ganglia (BG), ante-rior-temporal (AT), insula, lateral-temporal (LT), entorhinal (ERC), perirhinal (PRC), anterior fusi-form(AF), anterior hippocampus (AHIP) and posterior hippocampus (PHIP). Both Left (L) and Right (R) hemispheres were evaluated. Results: R-OF (p=0.059), L-OF (p<0.0005), L-AT (p=0.047) and L-AHIP (p=0.007) have a statistically significant effect on the variable occurrence of SD compared to bvFTD. The indicators with the highest value of the area under the curve (AUC) were R-AC (0.829), L-OF (0.808), L-AC (0.791) and L-AF (0.778). Highest sensitivity was achieved by R-OF (97%) and L-AF (75%). Highest specificity was achieved by L-OF (95%), L-AT (91%) followed by R-AC (84%). Best combination of sensitivity and specificity was achieved by L-AF (74%-79%), L-OF (56%-95%) and R-OF (97%-42%). Best combination of PPV and NPV was achieved by L-OF (90%-73%), L-AT (83%-72%) and R-AC (77%-77%). Conclusion: Visual rating scales can be a practical diagnostic tool in the characterization of patterns of atrophy in FTLD and may be used as an alternative to highly technical methods of quantification. © 2020 Bentham Science Publishers.
Συγγραφείς:
Manouvelou, S.
Koutoulidis, V.
Tsougos, I.
Tolia, M.
Kyrgias, G.
Anyfantakis, G.
Moulopoulos, L.-A.
Gouliamos, A.
Papageorgiou, S.
Περιοδικό:
Current Medical Imaging Reviews
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
adult; area under the curve; Article; brain cortex atrophy; diagnostic test accuracy study; differential diagnosis; disease duration; dorsal hippocampus; double blind procedure; entorhinal cortex; Fazekas Scale; female; frontal variant frontotemporal dementia; frontotemporal dementia; Global cortical atrophy scale; human; Koedam rating scale; left hemisphere; major clinical study; male; middle aged; Mini Mental State Examination; nuclear magnetic resonance imaging; Pasquier rating scale; perirhinal cortex; priority journal; rating scale; receiver operating characteristic; retrospective study; right hemisphere; Scheltens rating scale; semantic dementia; sensitivity and specificity; single photon emission computed tomography; ventral hippocampus; visual analog scale; Visual Rating Scale; atrophy; brain; brain mapping; computer assisted diagnosis; diagnostic imaging; differential diagnosis; frontotemporal dementia; neuropsychological test; observer variation; pathology; procedures; reproducibility; semantics, Atrophy; Brain; Brain Mapping; Diagnosis, Differential; Female; Frontotemporal Dementia; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Observer Variation; Reproducibility of Results; Semantics
DOI:
10.2174/1573405615666190225154834
