Τίτλος:
Healthcare resource utilization and associated cost analysis of the PROCLAIM study in patients with stage III non-small-cell lung cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To analyze patient-reported swallowing difficulties, healthcare resource utilization and associated costs during the PROCLAIM study. Methods: Patients with stage III non-squamous non-small cell lung cancer received pemetrexed-cisplatin (PemCis) combined with concurrent thoracic radiotherapy followed by consolidation pemetrexed, or concurrent chemoradiotherapy with etoposide-cisplatin (EtoCis) followed by standard consolidation chemotherapy. Patient - reported swallowing function was measured using diaries. Resource utilization (hospitalizations, transfusions, concomitant medications) was compared between treatment arms using Fisher’s exact test and independent t-test. Medical resource use costs were analyzed using nonparametric Wilcoxon rank sum test. Results: Patient-reported difficulty in swallowing function (diary score ≥4) was 33.8% in the PemCis arm and 29% in the EtoCis arm. Overall resource use, including hospitalizations, was similar between treatment arms; however, fewer patients in the PemCis arm received transfusions and selected concomitant medications. Concurrent phase analyses were consistent with the overall study. A significantly lower percentage of patients (31.1% vs. 40.8%) were hospitalized in the PemCis arm. Total costs were significantly higher in the PemCis arm. Other medical costs (excluding study treatment costs) during the concurrent phase were lower for patients in the PemCis arm, due to significantly lower hospitalization costs and lower use of concomitant medications. Subgroup analysis yielded similar results. Conclusions: Patient-reported difficulty in swallowing post-baseline and resource utilization were consistent with previously reported safety outcomes. In the overall study, higher total costs for PemCis were driven by study drug cost. When adjusting for treatment duration, other monthly medical costs were favorable to PemCis. Patients on pemetrexed remained longer on therapy, suggesting better tolerability. ClinicalTrials.gov identifier: NCT00686959. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Govindan, R.
Senan, S.
Dickgreber, N.
Provencio, M.
Wu, Y.-L.
Syrigos, K.
Parente, B.
Wilson, M.
Ziemiecki, R.
Chouaki, N.
Hossain, A.
San Antonio, B.
Winfree, K.
Vokes, E.E.
Περιοδικό:
Current Medical Research and Opinion
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
antibiotic agent; antifungal agent; antivirus agent; carboplatin; cisplatin; etoposide; fresh frozen plasma; granulocyte colony stimulating factor; granulocyte macrophage colony stimulating factor; neurokinin 1 receptor antagonist; nonsteroid antiinflammatory agent; paclitaxel; pemetrexed; serotonin antagonist; vinorelbine tartrate; antineoplastic agent, Article; cancer radiotherapy; cancer staging; cancer survival; chemoradiotherapy; comparative study; consolidation chemotherapy; controlled study; cost benefit analysis; dysphagia; esophagitis; febrile neutropenia; health care cost; health care utilization; hospital patient; hospitalization; hospitalization cost; human; major clinical study; multiple cycle treatment; non small cell lung cancer; overall survival; patient-reported outcome; progression free survival; randomized controlled trial; swallowing; treatment duration; adult; aged; cost; female; health care planning; lung tumor; male; middle aged; non small cell lung cancer; pathology; patient attitude; procedures, Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Costs and Cost Analysis; Female; Health Resources; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Patient Acceptance of Health Care
DOI:
10.1080/03007995.2019.1623185
