Περίληψη:
Background: We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections and the interaction with antibiotic therapy. Methods: This is a secondary analysis of a randomized controlled trial of patients with carbapenem-resistant gram-negative bacterial infections treated with colistin or colistin-meropenem combination. We evaluated patients with infection caused by carbapenem-resistant A. baumannii (CRAB) identified as colistin susceptible (CoS) at the time of treatment and compared patients in which the isolate was confirmed as CoS with those whose isolates were retrospectively identified as colistin resistant (CoR) when tested by broth microdilution (BMD). The primary outcome was 28-day mortality. Results: Data were available for 266 patients (214 CoS and 52 CoR isolates). Patients with CoR isolates had higher baseline functional capacity and lower rates of mechanical ventilation than patients with CoS isolates. All-cause 28-day mortality was 42.3% (22/52) among patients with CoR strains and 52.8% (113/214) among patients with CoS isolates (P =. 174). After adjusting for variables associated with mortality, the mortality rate was lower among patients with CoR isolates (odds ratio [OR], 0.285 [95% confidence interval {CI},. 118-.686]). This difference was associated with treatment arm: Mortality rates among patients with CoR isolates were higher in those randomized to colistin-meropenem combination therapy compared to colistin monotherapy (OR, 3.065 [95% CI, 1.021-9.202]). Conclusions: Colistin resistance determined by BMD was associated with lower mortality among patients with severe CRAB infections. Among patients with CoR isolates, colistin monotherapy was associated with a better outcome compared to colistin-meropenem combination therapy. Clinical Trials Registration: NCT01732250. © 2018 The Author(s) 2018.
Συγγραφείς:
Dickstein, Y.
Lellouche, J.
Ben Dalak Amar, M.
Schwartz, D.
Nutman, A.
Daitch, V.
Yahav, D.
Leibovici, L.
Skiada, A.
Antoniadou, A.
Daikos, G.L.
Andini, R.
Zampino, R.
Durante-Mangoni, E.
Mouton, J.W.
Friberg, L.E.
Dishon Benattar, Y.
Bitterman, R.
Neuberger, A.
Carmeli, Y.
Paul, M.
Zayyad, H.
Koppel, F.
Zak-Doron, Y.
Altunin, S.
Andria, N.
Stern, A.
Petersiel, N.
Raines, M.
Karban, A.
Eliakim-Raz, N.
Zusman, O.
Elbaz, M.
Atamna, H.
Babich, T.
Adler, A.
Levi, I.
Pavleas, I.
Kotsaki, A.
Iossa, D.
Bernardo, M.
Cavezza, G.
Bertolino, L.
Giuffre, G.
Giurazza, R.
Cuccurullo, S.
Galdo, M.
Murino, P.
Cristinziano, A.
Corcione, A.
Clara Pafundi, P.
Λέξεις-κλειδιά:
colistin; meropenem; antiinfective agent; carbapenem derivative; colistin, Acinetobacter infection; adult; aged; all cause mortality; antibiotic sensitivity; antibiotic therapy; Article; artificial ventilation; bacterial strain; bacterium isolate; broth dilution; carbapenem resistance; carbapenem resistant Acinetobacter baumannii; colistin resistance; combination drug therapy; female; functional status; Gram negative infection; human; major clinical study; male; monotherapy; mortality; mortality rate; multidrug resistant Acinetobacter baumannii; nonhuman; priority journal; randomized controlled trial (topic); retrospective study; secondary analysis; treatment outcome; Acinetobacter baumannii; Acinetobacter infection; clinical trial; controlled study; drug effect; microbial sensitivity test; middle aged; multicenter study; multidrug resistance; randomized controlled trial; statistical analysis, Acinetobacter baumannii; Acinetobacter Infections; Aged; Anti-Bacterial Agents; Carbapenems; Colistin; Data Interpretation, Statistical; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; Treatment Outcome
