Τίτλος:
Reduced peripheral blood superoxide dismutase 2 expression in sickle cell disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Sickle cell disease (SCD), a hereditary form of chronic hemolytic anemia, is characterized by acute vascular occlusion and chronic complications as pulmonary hypertension (PH), a hallmark of higher mortality. This study aimed to determine peripheral blood expression of superoxide dismutase 2 (SOD2), a major mitochondrial antioxidant enzyme in SCD patients on the mRNA level and compared it with SOD2 expression in healthy individuals. It also aimed to detect possible differences in SOD2 expression among patients with/without specific SCD complications and to detect possible correlations with patient laboratory parameters. SOD2 mRNA levels were significantly lower in SCD patients in comparison with controls and correlated with red blood cell count, reticulocyte count, platelet count, C-reactive protein, ferritin, and brain natriuretic peptide values. SCD patients with echocardiographic indications of PH featured significantly reduced SOD2 expression in comparison with patients without such indications. Consequently, SOD2 expression emerges as a potential biomarker of PH in SCD being a link among hemolysis, inflammation, iron overload, oxidative stress, and SCD cardiopathy. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Armenis, I.
Kalotychou, V.
Tzanetea, R.
Moyssakis, I.
Anastasopoulou, D.
Pantos, C.
Konstantopoulos, K.
Rombos, I.
Περιοδικό:
Annals of Hematology
Λέξεις-κλειδιά:
bilirubin; brain natriuretic peptide; C reactive protein; creatinine; ferritin; folic acid; hemoglobin; hemoglobin F; hemoglobin S; lactate dehydrogenase; manganese superoxide dismutase; messenger RNA; biological marker; brain natriuretic peptide; C reactive protein; ferritin; manganese superoxide dismutase; superoxide dismutase, adult; Article; bilirubin blood level; clinical article; controlled study; correlation analysis; creatinine blood level; echocardiography; erythrocyte count; female; ferritin blood level; folic acid blood level; gene expression; hematocrit; hemoglobin blood level; human; lactate dehydrogenase blood level; leukocyte count; male; platelet count; priority journal; protein blood level; pulmonary hypertension; reticulocyte count; sickle cell anemia; blood; clinical trial; enzymology; gene expression regulation; metabolism; pathology; sickle cell anemia, Adult; Anemia, Sickle Cell; Biomarkers; C-Reactive Protein; Female; Ferritins; Gene Expression Regulation, Enzymologic; Humans; Male; Natriuretic Peptide, Brain; Platelet Count; Reticulocyte Count; Superoxide Dismutase
DOI:
10.1007/s00277-019-03709-8
