Περίληψη:
Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life. © 2019 Wiley Periodicals, Inc.
Συγγραφείς:
Singer, S.
Amdal, C.D.
Hammerlid, E.
Tomaszewska, I.M.
Castro Silva, J.
Mehanna, H.
Santos, M.
Inhestern, J.
Brannan, C.
Yarom, N.
Fullerton, A.
Pinto, M.
Arraras, J.I.
Kiyota, N.
Bonomo, P.
Sherman, A.C.
Baumann, I.
Galalae, R.
Fernandez Gonzalez, L.
Nicolatou-Galitis, O.
Abdel-Hafeez, Z.
Raber-Durlacher, J.
Schmalz, C.
Zotti, P.
Boehm, A.
Hofmeister, D.
Krejovic Trivic, S.
Loo, S.
Chie, W.-C.
Bjordal, K.
Brokstad Herlofson, B.
Grégoire, V.
Licitra, L.
on behalf of the EORTC Quality of Life
the EORTC Head
Neck Cancer Groups
Λέξεις-κλειδιά:
aged; clinical trial; complication; Europe; female; head and neck tumor; human; male; middle aged; multimodality cancer therapy; phase 4 clinical trial; prospective study; psychology; psychometry; quality of life; questionnaire; reproducibility; sensitivity and specificity; very elderly, Aged; Aged, 80 and over; Combined Modality Therapy; Europe; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Psychometrics; Quality of Life; Reproducibility of Results; Sensitivity and Specificity; Surveys and Questionnaires
