Τίτλος:
Dysregulation of ß-catenin, WISP1 and TCF21 predicts disease-specific survival and primary response against radio(chemo)therapy in patients with locally advanced squamous cell carcinomas of the head and neck
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The objective of this study was to determine the prognostic and predictive impact of β-catenin, TCF21 and WISP1 expression in patients with squamous cell carcinomas of the head and neck who underwent primary radiotherapy or concomitant chemoradiotherapy. Study design: Prospective cohort study. Setting: University hospital. Participants: Protein expression profiles of β-catenin, TCF21, WISP1 and p16 were determined by immunohistochemical analyses in tissue samples of 59 untreated patients. Expression was correlated with different outcome parameters. Main outcome measures: Impact of TNM classification, grading, sex, age, gender, type of therapy, response to therapy and p16 status on disease-specific (DSS) and disease-free survival (DFS). Results: Patients with high expression of TCF21 were associated with significantly worse disease-specific survival (P = 0.005). In a multivariable analysis, TCF21 was a significant determinant of disease-specific survival. (HR 3.01; P = 0.036). Conversely, low expression of β-catenin (P = 0.025) and WISP1 (P = 0.037) revealed a better response to radiotherapy. Conclusion: Since data show that TCF21 is a prognostic factor for disease-specific survival and WISP1 and ß-catenin are predictive factors for clinical outcome after definitive radiotherapy, further studies are warranted to prove these preliminary but very promising findings. © 2019 John Wiley & Sons Ltd
Συγγραφείς:
Vyskocil, E.
Pammer, J.
Altorjai, G.
Grasl, M.C.
Parzefall, T.
Haymerle, G.
Janik, S.
Perisanidis, C.
Erovic, B.M.
Περιοδικό:
Clinical Otolaryngology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
beta catenin; carrier proteins and binding proteins; protein p16; transcription factor 7; unclassified drug; WNT1 induced secreted protein 1; basic helix loop helix transcription factor; beta catenin; CCN protein; CCN4 protein, human; oncoprotein; TCF21 protein, human; tumor marker, adult; advanced cancer; age; Article; cancer grading; cancer localization; cancer therapy; chemoradiotherapy; controlled study; disease association; disease free survival; female; gender; head and neck squamous cell carcinoma; human; immunohistochemistry; major clinical study; male; priority journal; prospective study; protein expression; sex; university hospital; Austria; biosynthesis; cancer staging; chemoradiotherapy; epidemiology; follow up; head and neck tumor; metabolism; middle aged; mortality; predictive value; prognosis; survival rate, Adult; Austria; Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Biomarkers, Tumor; CCN Intercellular Signaling Proteins; Chemoradiotherapy; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Prognosis; Prospective Studies; Proto-Oncogene Proteins; Squamous Cell Carcinoma of Head and Neck; Survival Rate
