Τίτλος:
The Role of Arterial Hypertension in Mitral Valve Regurgitation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose of Review: To review medical literature for evidence of association between hypertension and mitral regurgitation (MR) and summarize potential favorable effects of antihypertensive drugs on MR natural history and treatment. Recent Findings: Hypertension and MR are common diseases affecting a large proportion of the general population. Contemporary evidence suggests that hypertension may worsen the progression and prognosis of MR through augmented mechanical stress and increased regurgitation volume. Renin-angiotensin axis inhibitors, beta-blockers, and vasodilators have been tested in order to prevent or decrease primary or secondary MR. Summary: Although antihypertensive agents may improve hemodynamic parameters and left ventricular remodeling in primary MR, there is no strong evidence of benefit on clinical outcomes. On the other hand, a beneficial effect of these drugs on secondary MR is better established. Moreover, there are no studies evaluating a possible benefit of lower blood pressure targets in MR. Randomized controlled trials are warranted to elucidate the precise role of antihypertensive therapy on treatment of MR. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Katsi, V.
Georgiopoulos, G.
Magkas, N.
Oikonomou, D.
Virdis, A.
Nihoyannopoulos, P.
Toutouzas, K.
Tousoulis, D.
Περιοδικό:
Current Hypertension Reports
Εκδότης:
Current Medicine Group LLC 1
Λέξεις-κλειδιά:
angiotensin antagonist; atenolol; beta adrenergic receptor blocking agent; bumetanide; captopril; carvedilol; enalapril; furosemide; hydralazine; isosorbide dinitrate; lisinopril; losartan; metoprolol; nicorandil; nifedipine; nitroprusside sodium; placebo; quinapril; ramipril; renin inhibitor; vasodilator agent; antihypertensive agent, blood pressure; cardiovascular parameters; cardiovascular risk; clinical outcome; disease association; disease course; follow up; heart hemodynamics; heart ventricle remodeling; human; hypertension; mechanical stress; mitral valve regurgitation; pathophysiology; prevalence; prognosis; Review; systematic review; treatment outcome; complication; hypertension; mitral valve regurgitation, Adrenergic beta-Antagonists; Antihypertensive Agents; Humans; Hypertension; Mitral Valve Insufficiency; Ventricular Remodeling
DOI:
10.1007/s11906-019-0928-9
