Τίτλος:
Successful long-term hematological and immunological reconstitution by autologous cord blood transplantation combined with post-transplant immunosuppression in two children with severe aplastic anemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
aUCBT is a valuable curative option in pediatric patients with refractory idiopathic SAA and no available matched sibling or unrelated donors. Experience in the use of autologous cord blood units in patients with SAA is limited and private for-profit cord blood-banking programs are controversial. We report the successful treatment of two patients with SAA, aged 15 and 24 months, with autologous cord blood combined with immunosuppression. After conditioning with 200 mg/kg cyclophosphamide and ATG, 7.5 mg/kg, 32.2 × 107/kg, and 3.8 × 107/kg autologous cord blood nucleated cells were infused, respectively. One of our patients underwent transplantation after failure of IST. Both patients received post-transplant immunosuppression with cyclosporine for 12 months. They remain disease-free 6 years post-transplantation. © 2018 Wiley Periodicals, Inc.
Συγγραφείς:
Georgia, A.
Christina, O.
Aikaterini, K.
Elda, I.
Anna, K.
Anna, P.
Natalia, T.
Maria, F.
Antonios, K.
George, V.
Ioulia, P.
Evgenios, G.
Vasiliki, K.
Περιοδικό:
Pediatric Transplantation
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
antibiotic agent; cyclophosphamide; cyclosporine; fluconazole; pentamidine; thymocyte antibody; cyclosporine; immunosuppressive agent, antifungal therapy; aplastic anemia; Article; blood autotransfusion; bone marrow biopsy; case report; child; clinical article; cord blood stem cell transplantation; cytogenetics; disease severity; Fanconi anemia; human; human tissue; immune reconstitution; immunosuppressive treatment; leukocyte count; male; pallor; pancytopenia; petechia; physical examination; postoperative care; preschool child; prophylaxis; Pseudomonas infection; remission; aplastic anemia; autotransplantation; blood; cord blood stem cell transplantation; immunology; infant; multimodality cancer therapy; procedures, Anemia, Aplastic; Child, Preschool; Combined Modality Therapy; Cord Blood Stem Cell Transplantation; Cyclosporine; Humans; Immunosuppressive Agents; Infant; Male; Transplantation, Autologous
