Τίτλος:
MR imaging features and tumor biomarkers of screen-detected and non-screen detected breast cancers: preliminary results of a comparative study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To investigate differences in clinical features, MRI findings and tumor biomarker characteristics in screen-detected (SCD) and non-screendetected (NSCD) cancers. Material and methods: A total of 62 women (mean age, 48.4 years; range, 33–68 years) with biopsy confirmed breast cancer who underwent preoperative breast MRI were retrospectively evaluated by two expert radiologists. The women were divided into two groups according to the mode of cancer detection (Group A: screen- detected, Group B: non-screen/symptomatic cancer) and clinical, histopathological, MRI characteristics and biomarker features in each group were evaluated. Results: NSCD tumors had significantly greater size (3.5 cm vs. 2.1 cm) and Ki-67 expression (68.4% vs. 41.7%) in comparison to SCD cancers. NSCD cancers were less likely to have strongly positive progesterone receptors (Pr) and more likely to have Ki-67 > 15% or positive nodal status (47.4% vs. 8.3%). Increased breast density (ACR C and D: 78.9% vs. 50%ACR A and B) and intense background parenchymal enhancement (BPE, moderate/marked: 42.1% vs. 8.3% minimal/mild) were significantly more frequent in NSCD cases. Conclusion: NSCD cancers had higher prevalence of poor prognostic characteristics in comparison to SCD tumors, including larger tumor size, higher Ki-67 index, and positive nodes. Increased fibroglandular tissue and intense BPE were both strongly associated with NSCD cancers, supporting their use as potential MR biomarkers in breast cancer risk models. © 2018 Elsevier Inc.
Συγγραφείς:
Panourgias, E.
Bourgioti, C.
Koureas, A.
Koutoulidis, V.
Metaxas, G.
Moulopoulos, L.A.
Περιοδικό:
Clinical Imaging
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
Biomarkers; Diseases; Magnetic resonance imaging; Medical imaging; Risk assessment; Tumors, Breast Cancer; Breast cancer risk; Breast density; Breast magnetic-resonance imaging; Clinical features; Comparative studies; Fibroglandular tissue; Progesterone receptor, Feature extraction, Ki 67 antigen; tumor marker; tumor marker, adult; aged; Article; breast biopsy; breast cancer; breast density; cancer diagnosis; clinical feature; comparative study; controlled study; diagnostic test accuracy study; female; histopathology; human; human tissue; lymph node; major clinical study; nuclear magnetic resonance imaging; preliminary data; preoperative evaluation; priority journal; protein expression; retrospective study; tumor volume; breast; breast density; breast tumor; early cancer diagnosis; mass screening; metabolism; middle aged; nuclear magnetic resonance imaging; pathology; procedures; prognosis, Adult; Aged; Biomarkers, Tumor; Breast; Breast Density; Breast Neoplasms; Early Detection of Cancer; Female; Humans; Magnetic Resonance Imaging; Mass Screening; Middle Aged; Prognosis; Retrospective Studies
DOI:
10.1016/j.clinimag.2018.08.011
