Τίτλος:
Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been proposed to play a pivotal role in male infertility due to their anabolic effects. The aim of this study was to investigate possible associations between seminal plasma levels of GH and IGF-1 and sperm parameters. Fifty men participated in this study. Semen analysis was performed, while cell-free seminal plasma was collected following sperm centrifugation. Seminal plasma concentrations of IGF-1 and GH were determined by enzyme-linked immunosorbent assay (ELISA). Due to the presence of asthenozoospermia in all participants who presented with abnormal sperm parameters, the participants were further subdivided into normal (group A), asthenozoospermic (group B) and asthenozoospermic plus at least one additional abnormal parameter (group C). A marginally nonsignificant statistical difference (p = 0.063) was revealed between the GH levels corresponding to the asthenozoospermic and the normal group with the latter presenting with higher GH levels. A statistically significant positive correlation (p < 0.05) was noted between levels of GH and IGF-1 in group C. The above relationship has also been observed in men with low sperm concentration, vitality, volume and abnormal morphology. These novel findings require further investigation in order for the biological significance of those associations to be clarified. © 2018 Blackwell Verlag GmbH
Συγγραφείς:
Simopoulou, M.
Philippou, A.
Maziotis, E.
Sfakianoudis, K.
Nitsos, N.
Bakas, P.
Tenta, R.
Zevolis, E.
Pantos, K.
Koutsilieris, M.
Περιοδικό:
Andrologia : Official Journal of Comite International De Andrologia (CIDA)
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
growth hormone; somatomedin C; biological marker; human growth hormone; IGF1 protein, human; somatomedin C, adult; Article; asthenospermia; cell structure; centrifugation; concentration process; controlled study; disease association; enzyme linked immunosorbent assay; human; human cell; major clinical study; male; male fertility; male genital tract parameters; male infertility; semen analysis; seminal plasma; spermatozoon density; asthenospermia; chemistry; middle aged; sperm; spermatozoon count, Adult; Asthenozoospermia; Biomarkers; Enzyme-Linked Immunosorbent Assay; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Semen; Semen Analysis; Sperm Count
