Τίτλος:
PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT). Patients and Methods: We measured levels of PlGF, sFlt-1 and vWF:antigen in patients with NTDT of beta-thalassemia genotype, and correlated them with erythrocytic indices and markers of iron overload, inflammation, and tissue hypoxia. Thirty-four NTDT patients with mean hemoglobin level of 8.4 g/dL were included in the study along with 20 apparently healthy individuals who served as controls. Results: Ferritin, LDH, and hs-CRP were higher in patients as compared to controls. We found significant differences between patients and controls in regard to levels of PlGF (52.2 vs 17.2 pg/mL, P <.001), sFlt-1/PlGF (2 vs 4.7, P <.001), and vWF:antigen (88 vs 77.1 IU/dL, P <.01). There was a strong correlation of ferritin with PlGF (r =.653, P <.001) and with vWF:antigen (r =.503, P =.003). Conclusions: In this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT. High vWF:antigen expressing endothelial damage may be associated with specific NTDT comorbidities. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Συγγραφείς:
Kelaidi, C.
Kattamis, A.
Apostolakou, F.
Poziopoulos, C.
Lazaropoulou, C.
Delaporta, P.
Kanavaki, I.
Papassotiriou, I.
Περιοδικό:
European Journal of Haematology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
C reactive protein; endothelin 1; ferritin; hemoglobin; hemoglobin F; hydroxyurea; iron; lactate dehydrogenase; placental growth factor; vasculotropin receptor 1; von Willebrand factor; biological marker; FLT1 protein, human; iron; membrane protein; PIGF protein, human; vasculotropin receptor 1, adult; angiogenesis; Article; beta thalassemia; clinical article; comorbidity; controlled study; disease association; endothelial dysfunction; erythrocyte; erythropoiesis; female; ferritin blood level; genotype; hemoglobin blood level; human; hypoxemia; immunoturbidimetry; iron chelation; iron overload; lactate dehydrogenase blood level; male; non transfusion dependent thalassemia; non transfusion dependent thalassemia; oxidative stress; priority journal; pulmonary hypertension; thalassemia; adolescent; blood; metabolism; middle aged; sensitivity and specificity; thalassemia; vascular endothelium; young adult, Adolescent; Adult; Biomarkers; Endothelium, Vascular; Female; Humans; Iron; Male; Membrane Proteins; Middle Aged; Sensitivity and Specificity; Thalassemia; Vascular Endothelial Growth Factor Receptor-1; Young Adult
