Περίληψη:
Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change. © 2017 European Academy of Dermatology and Venereology
Συγγραφείς:
Theut Riis, P.
Saunte, D.M.
Benhadou, F.
del Marmol, V.
Guillem, P.
El-Domyati, M.
Abdel-Wahab, H.
Antoniou, C.
Dessinioti, C.
Gürer, M.A.
Beksaç, B.
Szepietowski, J.C.
Matusiak, L.
Emtestam, L.
Lapins, J.
Riad, H.
Doss, N.
Massa, A.F.
Hamzavi, I.
Nicholson, C.
Dolenc-Voljc, M.
Kim, K.H.
Ohn, J.
Zouboulis, C.C.
Karagiannidis, I.
Mokos, Z.B.
Durinec, P.
Jemec, G.B.E.
Λέξεις-κλειδιά:
adult; Article; body mass; controlled study; cross-sectional study; descriptive research; disease severity; exploratory research; family history; female; human; major clinical study; male; obesity; prediction; priority journal; rash; smoking; suppurative hidradenitis; young adult; classification; comparative study; complication; genetics; onset age; protection; risk factor; severity of illness index; suppurative hidradenitis, Adult; Age of Onset; Body Mass Index; Cross-Sectional Studies; Female; Hidradenitis Suppurativa; Humans; Male; Obesity; Protective Factors; Risk Factors; Severity of Illness Index; Smoking; Young Adult
