Τίτλος:
Differential expression of cord blood neurotrophins in gestational diabetes: the impact of fetal growth abnormalities
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Gestational diabetes mellitus (GDM) may induce fetal macrosomia or growth restriction and is associated with later offspring neurodevelopmental disorders. We aimed to determine whether neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-4 (NT-4) are differentially expressed in cord blood samples at birth in large-for-gestational-age (LGA), intrauterine-growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) offspring of diabetic mothers, as compared to AGA controls from non-diabetic mothers. Methods: BDNF, NGF and NT-4 concentrations were prospectively determined in 80 cord blood samples from LGA (n = 15), IUGR (n = 12) and AGA (n = 33) diabetic, as well as from AGA normal (controls, n = 20) singleton full-term pregnancies. Results: Fetal BDNF concentrations considerably decreased in GDM, as compared with normal pregnancies [(b = −2.836, 95%CI −5.067 to (−0.604), p = 0.013)] and were higher in females (b = 2.298, 95%CI 0.357–4.238, p = 0.021). Cord blood NGF concentrations were lower in IUGR than AGA infants (p = 0.038). Conclusions: BDNF is down-regulated in the fetus exposed to GDM, independently of the fetal growth pattern, probably representing a candidate mechanism underlying the association between maternal diabetes and later psychopathology. IUGR fetuses born to diabetic mothers present with NGF deficiency, which may contribute to their long-term neurodevelopmental sequelae. Gender-dependent differences in fetal BDNF may partly explain the higher prevalence of adverse neurodevelopmental outcomes following brain insults in male infants. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Briana, D.D.
Papastavrou, M.
Boutsikou, M.
Marmarinos, A.
Gourgiotis, D.
Malamitsi-Puchner, A.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
brain derived neurotrophic factor; nerve growth factor; neurotrophin; neurotrophin 4; nerve growth factor, adult; analysis of variance; Article; birth weight; chromosome aberration; controlled study; down regulation; echography; female; fetus growth; gestational age; human; Kolmogorov Smirnov test; large for gestational age; major clinical study; male; maternal age; parity; pregnancy diabetes mellitus; prevalence; priority journal; prospective study; protein analysis; protein expression; umbilical cord blood; upregulation; blood; case control study; fetus blood; intrauterine growth retardation; macrosomia; metabolism; newborn; pregnancy, Adult; Case-Control Studies; Female; Fetal Blood; Fetal Growth Retardation; Fetal Macrosomia; Humans; Infant, Newborn; Male; Nerve Growth Factors; Pregnancy
DOI:
10.1080/14767058.2017.1281907
