Τίτλος:
Association of brain natriuretic peptide and adrenomedullin plasma levels with left ventricular filling pressures in end-stage renal disease patients on hemodialysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
OBJECTIVE: Adrenomedullin (ADM) and brain natriuretic peptide (BNP) are known to be associated with elevated left ventricular filling pre ssures. However, little is known about this association in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF). Our objective was to evaluate the potential association between E/e' ratio and plasma levels of BNP and ADM in end-stage renal disease (ESRD) patients with preserved LVEF undergoing chronic hemodialysis. PATIENTS AND METHODS: The study group enrolled 62 ESRD patients treated with hemodialysis three times weekly. BNP and ADM plasma concentration measurements and echocardiographic examination were performed 30 minutes after hemodialysis. E/e' ratio, evaluated by Tissue Doppler imaging and measured at the basal septum, was used as a surrogate marker for assessing left ventricular filling pressures. RESULTS: The mean age of patients was 62 ± 25 years. The mean BNP and ADM values after hemodialysis were 0.40 ± 6.73 ng/ml and 0.06 ± 2.12 ng/ml, respectively. Elderly patients with hypertrophied left ventricles and larger left atria displayed high er E/e' value s. BN P (r = 0. 324. p = 0.018) and ADM (r = 0.319, p = 0.042) plasma levels were positively and significantly associated with E/e?. Multivariate regression analysis including BNP, ADM, age, hemodialysis duration, left ventricular end-systolic volume index, LVEF, left ventricular mass index and left atrium volume index, revealed that ADM (p-value 0.025) but not BNP levels, were independently associated with the E/e' ratio. CONCLUSIONS: ADM, but not BNP, was independently associated with septal E/e' in HD patients with preserved LVEF. ADM plasma levels can be used as a surrogate index to assess left ventricular filling pressures in HD patients. © 2018 European Review for Medical and Pharmacological Sciences. All rights reserved.
Συγγραφείς:
Tzatzaki, E.
Spartalis, M.
Kamperidis, V.
Spartalis, E.
Konstantinou, D.
Kapoukranidou, D.
Karvounis, H.
Περιοδικό:
European Review for Medical and Pharmacological Sciences
Εκδότης:
Verduci Editore s.r.l
Λέξεις-κλειδιά:
adrenomedullin; brain natriuretic peptide; ADM protein, human; adrenomedullin; biological marker; brain natriuretic peptide, adult; age; aged; Article; cardiovascular parameters; controlled study; disease association; echocardiography; end stage renal disease; female; Greece; heart atrium enlargement; heart left ventricle ejection fraction; heart left ventricle endsystolic volume; heart left ventricle filling pressure; heart left ventricle hypertrophy; heart left ventricle mass index; heart septum; hemodialysis; human; major clinical study; male; middle aged; prospective study; protein blood level; tissue Doppler imaging; treatment duration; blood; chronic kidney failure; diagnostic imaging; heart left ventricle function; physiology; very elderly, Adrenomedullin; Adult; Aged; Aged, 80 and over; Biomarkers; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Renal Dialysis; Ventricular Function, Left
DOI:
10.26355/eurrev-201811-16422
