Τίτλος:
An update on predictive biomarkers for major adverse cardiovascular events in patients undergoing vascular surgery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cardiovascular complications signify a major cause of morbidity and mortality in patients undergoing vascular surgery adversely affecting both short- and long-term prognosis. During the last decade, unmet needs for a distinct cardiovascular risk assessment have led to an intensive research for establishment of biomarkers with sufficient predictive value. This literature review aims in examining the value of several biomarkers in predicting the incidence of major adverse cardiac events in vascular surgery patients. We reviewed the English language literature and analyzed the biomarkers as independent predictors or in correlation with other factors. We found several biomarkers showing a significant predictive value for a major adverse cardiovascular event in patients undergoing vascular surgery. These biomarkers can be used in clinical practice as outcome predictors, although sensitivity and specificity varies. Detection of subclinical cardiovascular damage may improve total risk estimation and facilitate clinical assessment of patients at risk for future cardiovascular events. The wide variety of sensitivity and specificity in predicting a MACE of these biomarkers exert the need for future trials in which these markers will be tested as adjunctive tools of cardiovascular risk estimation scoring systems. © 2016 Elsevier Inc. All rights reserved.
Συγγραφείς:
Patelis, N.
Kouvelos, G.N.
Koutsoumpelis, A.
Moris, D.
Matsagkas, M.I.
Arnaoutoglou, E.
Περιοδικό:
Journal of Clinical Anesthesia
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
brain natriuretic peptide; C reactive protein; copeptin; hemoglobin; troponin; biological marker; C reactive protein; copeptin; glycopeptide; hemoglobin; troponin, cardiovascular disease; cardiovascular risk; clinical assessment; clinical practice; correlational study; hematocrit; hemoglobin blood level; human; leukocyte count; outcome assessment; patient risk; predictive value; priority journal; randomized controlled trial (topic); Review; scoring system; sensitivity and specificity; vascular surgery; adverse effects; blood; Cardiovascular Diseases; metabolism; procedures; prognosis; risk assessment; vascular surgery, Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Glycopeptides; Hematocrit; Hemoglobins; Humans; Prognosis; Risk Assessment; Troponin; Vascular Surgical Procedures
DOI:
10.1016/j.jclinane.2016.03.021
