Τίτλος:
Immunosenescence in patients with chronic systolic heart failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Chronic heart failure (CHF) is characterized by hemodynamic compromise, neurohormonal and immune activation. We sought to examine the presence and severity of immunosenescence and its relation with the stages of CHF. Methods We enrolled 86 consecutive stable systolic CHF patients and examined the relationship of leukocyte and lymphocyte subpopulation counts by flow cytometry with their functional status according to New York Heart Association (NYHA) class. Results Patients with advanced heart failure were characterized by significantly increased neutrophil and reduced lymphocyte counts. T-helper cells were increased, whereas B-cells and T cytotoxic cells were decreased. T-helper cells exhibited significant differentiation and aging across the NYHA classes; naïve T-cells, CD4+ CD45RA+, were significantly reduced in NYHA Class IV and memory T-cells, CD4+ CD45RO+, were significantly increased. Conclusion Patients with CHF develop intense T-cell differentiation and aging. The presence of significant immunosenescence in advanced CHF may indicate a population at increased risk for adverse events. © 2016 Italian Federation of Cardiology.
Συγγραφείς:
Xydonas, S.
Parissis, J.
Lioni, L.
Kapsimali, V.
Psarra, E.
Farmakis, D.
Kremastinos, D.
Lekakis, J.
Sideris, A.
Tsirogianni, A.
Filippatos, G.
Περιοδικό:
Journal of cardiovascular medicine (Hagerstown, Md.)
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
creatinine; spironolactone; urea, aged; Article; B lymphocyte; CD4 CD8 ratio; CD4+ T lymphocyte; CD8+ T lymphocyte; chronic kidney disease; chronic obstructive lung disease; controlled study; creatinine blood level; cytotoxic T lymphocyte; female; flow cytometry; helper cell; human; immunosenescence; leukocyte function; lymphocyte count; lymphocyte differentiation; lymphocyte function; lymphocyte subpopulation; major clinical study; male; memory T lymphocyte; neutrophil count; New York Heart Association class; systolic heart failure; T lymphocyte; T lymphocyte activation; urea blood level; chronic disease; heart left ventricle function; hemodynamics; immunology; middle aged; pathophysiology; systolic heart failure; very elderly, Aged; Aged, 80 and over; Chronic Disease; Female; Flow Cytometry; Heart Failure, Systolic; Hemodynamics; Humans; Immunosenescence; Lymphocyte Subsets; Male; Middle Aged; Ventricular Function, Left
DOI:
10.2459/JCM.0000000000000372
