Τίτλος:
Valproate effect on ketosis in children under ketogenic diet
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction Although ketogenic diet has been proven useful in the management of intractable seizures, interactions with other medicines have been reported. This study reports two patients on co-administration with ketogenic diet and valproate appearing undesirable side effects after increase or decrease of valproate pharmaceutical levels. Methods Totally 75 patients suffering from drug-resistant epilepsy were treated with ketogenic diet in our departments. Their age varied from 6 months to 9 years. All patients were followed for at least 12 months and up to five years. Clinical and laboratory variables have been regularly assessed. Results In 75 patients treated with ketogenic diet and valproate at the same time treatment was well tolerated. Two patients presented mild to moderate undesirable effects. In these patients the removal of valproate treatment resulted in an increase of ketosis with respective clinical signs. The conversion of the diet from 4:1 to 1:1 and 2,5:1 respectively resulted in reduction of ketosis and clinical improvement. Conclusion In the majority of cases co-administration of valproate and ketogenic diet seems to be safe. In two cases, valproate appeared to have a negative effect on ketosis (and weaning it led to over-ketosis). This interaction is worthy of future study. © 2016 European Paediatric Neurology Society.
Συγγραφείς:
Spilioti, M.
Pavlou, E.
Gogou, M.
Katsanika, I.
Papadopoulou-Alataki, E.
Grafakou, O.
Gkampeta, A.
Dinopoulos, A.
Evangeliou, A.
Περιοδικό:
European Journal of Paediatric Neurology
Εκδότης:
W.B. Saunders Ltd
Λέξεις-κλειδιά:
topiramate; valproic acid; zonisamide; anticonvulsive agent; valproic acid, Article; child; clinical assessment; complex partial seizure; drug dose reduction; drug resistant epilepsy; drug safety; drug tolerability; drug withdrawal; epileptic discharge; fatigue; female; human; infant; ketoacidosis; ketogenic diet; Lennox Gastaut syndrome; major clinical study; male; preschool child; priority journal; retrospective study; somnolence; treatment response; xerostomia; adolescent; adverse effects; chemically induced; clinical trial; diet therapy; epilepsy; Ketosis; multimodality cancer therapy, Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Epilepsy; Female; Humans; Infant; Ketogenic Diet; Ketosis; Male; Valproic Acid
DOI:
10.1016/j.ejpn.2016.04.003
