Τίτλος:
Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. © 2016, Springer-Verlag Berlin Heidelberg.
Συγγραφείς:
Georgitsi, M.D.
Vitoros, V.
Panou, C.
Tsangaris, I.
Aimoniotou, E.
Gatselis, N.K.
Chasou, E.
Kouliatsis, G.
Leventogiannis, K.
Velissaris, D.
Belesiotou, E.
Dioritou-Aggaliadou, O.
Giannitsioti, E.
Netea, M.G.
Giamarellos-Bourboulis, E.J.
Giannikopoulos, G.
Alexiou, Z.
Voloudakis, N.
Koutsoukou, A.
Περιοδικό:
European Journal of Clinical Microbiology and Infectious Diseases
Λέξεις-κλειδιά:
interleukin 8; interleukin 8, abdominal infection; acute pyelonephritis; adult; aged; allele; APACHE; Article; bacteremia; clinical feature; community acquired pneumonia; comparative study; controlled study; disease course; disease severity; female; gene frequency; genetic association; genotype; heterozygote; human; major clinical study; male; multicenter study; polymerase chain reaction; priority journal; promoter region; protein blood level; restriction fragment length polymorphism; septic shock; single nucleotide polymorphism; adolescent; bacterial infection; clinical trial; genetic predisposition; genetics; genotype; middle aged; pathology; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Infections; Female; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-8; Male; Middle Aged; Polymorphism, Single Nucleotide; Young Adult
DOI:
10.1007/s10096-015-2571-y
