Τίτλος:
Multiple sclerosis and Parkinson’s disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
There is still an open debate whether multiple sclerosis (MS) lesions can cause parkinsonian symptoms, or the coexistence of both diseases in the same patient is accidental. Moreover, α-synuclein (α Syn), the hallmark of Parkinson’s disease (PD) seems also to play a crucial role in MS. So far, 42 cases of co-occurrence of parkinsonism and MS have been reported, but CSF α Syn measurement is lacking. To our knowledge, we report the first case with concomitant MS and PD diagnosis based on both clinico-radiological and CSF α Syn findings and review of literature. © 2015, Springer-Verlag Italia.
Συγγραφείς:
Bougea, A.
Kapaki, E.
Paraskevas, G.P.
Kilidireas, K.
Andreadou, E.
Περιοδικό:
Neurological Sciences
Εκδότης:
Springer-Verlag Italia s.r.l.
Λέξεις-κλειδιά:
alpha synuclein; dopamine transporter; immunoglobulin G; ioflupane i 123; levodopa; oligoclonal band; alpha synuclein, adult; Article; brain atrophy; brain damage; case report; cerebrospinal fluid; clonus; demyelination; drug dose titration; enzyme linked immunosorbent assay; Expanded Disability Status Scale; female; Greece; human; middle aged; Mini Mental State Examination; motor dysfunction; multiple sclerosis; neuroimaging; nuclear magnetic resonance imaging; Parkinson disease; parkinsonism; putamen; rigidity; spasticity; thalamus; Unified Parkinson Disease Rating Scale; weakness; white matter lesion; brain; complication; differential diagnosis; multiple sclerosis; Parkinson disease; Parkinsonian Disorders; pathology; treatment outcome, alpha-Synuclein; Brain; Diagnosis, Differential; Female; Humans; Middle Aged; Multiple Sclerosis; Parkinson Disease; Parkinsonian Disorders; Treatment Outcome
DOI:
10.1007/s10072-015-2308-9
