Τίτλος:
Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aspergillus fumigatus is commonly found in cystic fibrosis (CF) airways. Our aim was to assess the relationship between A. fumigatus chronic colonization and lung function in CF patients. A case–control study of CF patients born from 1989 to 2002 was performed. Medical records were reviewed from the time of initial diagnosis until December 2013. Chronic colonization was defined as two or more positive sputum cultures in a given year. Each patient chronically colonized with A. fumigatus was matched with three control patients (never colonized by A. fumigatus) for age, sex, and year of birth (±3 years). A number of parameters were recorded and analyzed prospectively. The primary outcome measure was the difference in forced expiratory volume in 1 s (FEV1) in percent predicted between groups. Linear mixed models were used for longitudinal analyses to evaluate the relationship between A. fumigatus chronic colonization and lung function during a 7-year period and study the lung function 4 years before the time of enrollment (t0). Twenty patients had chronic colonization and were matched with 60 controls. A significant difference in lung function was detected throughout the 7-year period after adjustment for confounders (est = 8.66, p = 0.020). Four years before t0, FEV1 baseline was the only factor associated with the course of lung function (est = 0.64, p < 0.001) and was significantly different between groups (p = 0.001). In conclusion, a decreased FEV1 baseline appears to be a risk factor for chronic colonization by A. fumigatus, which, in turn, may cause a faster deterioration of lung function. © 2015, Springer-Verlag Berlin Heidelberg.
Συγγραφείς:
Noni, M.
Katelari, A.
Dimopoulos, G.
Doudounakis, S.-E.
Tzoumaka-Bakoula, C.
Spoulou, V.
Περιοδικό:
European Journal of Clinical Microbiology and Infectious Diseases
Λέξεις-κλειδιά:
adult; antibiotic therapy; Article; Aspergillus fumigatus; case control study; controlled study; cystic fibrosis; female; follow up; forced expiratory volume; fungal colonization; human; lung function; major clinical study; male; medical record review; priority journal; sputum culture; adolescent; aspergillosis; Aspergillus fumigatus; child; chronic disease; complication; cystic fibrosis; isolation and purification; longitudinal study; lung function test; pathology; prospective study, Adolescent; Aspergillosis; Aspergillus fumigatus; Case-Control Studies; Child; Chronic Disease; Cystic Fibrosis; Humans; Longitudinal Studies; Male; Prospective Studies; Respiratory Function Tests
DOI:
10.1007/s10096-015-2474-y
