Τίτλος:
Catheter-based renal denervation for resistant hypertension: Twenty-four month results of the EnligHTN™ i first-in-human study using a multi-electrode ablation system
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Long term safety and efficacy data of multi-electrode ablation system for renal denervation (RDN) in patients with drug resistant hypertension (dRHT) are limited. Methods and results We studied 46 patients (age: 60 ± 10 years, 4.7 ± 1.0 antihypertensive drugs) with drug resistant hypertension (dRHT). Reduction in office BP at 24 months from baseline was - 29/- 13 mm Hg, while the reduction in 24-hour ambulatory BP and in home BP at 24 months were - 13/- 7 mm Hg and - 11/- 6 mm Hg respectively (p < 0.05 for all). A correlation analysis revealed that baseline office and ambulatory BP were related to the extent of office and ambulatory BP drop. Apart from higher body mass index (33.3 ± 4.7 vs 29.5 ± 6.2 kg/m2, p < 0.05), there were no differences in patients that were RDN responders defined as ≥ 10 mm Hg decrease (74%, n = 34) compared to non-responders. Stepwise logistic regression analysis revealed no prognosticators of RDN response (p = NS for all). At 24 months there were no new serious device or procedure related adverse events. Conclusions The EnligHTN I study shows that the multi-electrode ablation system provides a safe method of RDN in dRHT accompanied by a clinically relevant and sustained BP reduction. © 2015 Elsevier Ireland Ltd.
Συγγραφείς:
Tsioufis, C.P.
Papademetriou, V.
Dimitriadis, K.S.
Kasiakogias, A.
Tsiachris, D.
Worthley, M.I.
Sinhal, A.R.
Chew, D.P.
Meredith, I.T.
Malaiapan, Y.
Thomopoulos, C.
Kallikazaros, I.
Tousoulis, D.
Worthley, S.G.
Περιοδικό:
International Journal of Cardiology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
ablation device; adult; Article; blood pressure monitoring; blood pressure regulation; body mass; clinical article; evidence based medicine; female; human; kidney denervation; male; multi electrode ablation system; outcome assessment; patient safety; priority journal; prognosis; resistant hypertension; therapy effect; treatment response; adverse effects; aged; blood pressure; catheter ablation; clinical trial; drug resistance; electrode; follow up; hypertension; innervation; kidney; middle aged; multicenter study; pathophysiology; physiology; procedures; prospective study; sympathectomy; treatment outcome, Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Catheter Ablation; Drug Resistance; Electrodes; Female; Follow-Up Studies; Humans; Hypertension; Kidney; Male; Middle Aged; Prospective Studies; Sympathectomy; Treatment Outcome
DOI:
10.1016/j.ijcard.2015.08.069
