Τίτλος:
Evaluation of bone involvement in patients with Gaucher disease: A semi-quantitative magnetic resonance imaging method (using ROI estimation of bone lesion) as an alternative method to semi-quantitative methods used so far
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim of this study was to evaluate bone involvement in patients with Gaucher disease (GD) and to propose a novel semi-quantitative magnetic resonance imaging (MRI) staging. Methods: MRI of the lumbar spine, femur, and tibia was performed in 24 patients with GD and 24 healthy controls. We also measured circulating levels of C-C motif ligand-3 (CCL-3) chemokine, C-telopeptide of collagen type-1 (CTX), and tartrate-resistant acid phosphatase isoform type-b (TRACP-5b). Results: We used the following staging based on MRI data: stage I: region of interest (ROI) 1/2 of normal values and bone infiltration up to 30%; stage II: ROI 1/3 of normal values and bone infiltration from 30 to 60%; stage III: ROI 1/4 of normal values and bone infiltration from 60% to 80%; and stage IV: detection of epiphyseal infiltration, osteonecrosis and deformity regardless of the ROI's values. All but two patients had abnormal MRI findings: 9 (37.5%), 6 (25%), 3 (12.5%), and 4 (16.7%) had stages I-IV, respectively. Patients with GD had elevated chitotriosidase, serum TRACP-5b, and CCL-3 levels (P < 0.001). Conclusions: We propose an easily reproducible semi-quantitative scoring system and confirm that patients with GD have abnormal MRI bone findings and enhanced osteoclast activity possibly due to elevated CCL-3. © 2015 John Wiley & Sons A/S.
Συγγραφείς:
Komninaka, V.
Kolomodi, D.
Christoulas, D.
Marinakis, T.
Papatheodorou, A.
Repa, K.
Voskaridou, E.
Revenas, K.
Terpos, E.
Περιοδικό:
European Journal of Haematology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
acid phosphatase tartrate resistant isoenzyme; carboxy terminal telopeptide; chitotriosidase; collagen type 1; CXCL3 chemokine; imiglucerase; biological marker, adolescent; adult; aged; Article; bone marrow; bone necrosis; clinical article; controlled study; disease activity; female; femur; Gaucher disease; human; lumbar spine; male; middle aged; normal value; nuclear magnetic resonance imaging; priority journal; scoring system; tibia; treatment duration; vision; bone; Bone Diseases; complication; Gaucher disease; genetics; metabolism; pathology; procedures; severity of illness index; young adult, Adolescent; Adult; Aged; Biomarkers; Bone and Bones; Bone Diseases; Female; Gaucher Disease; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Severity of Illness Index; Young Adult
