Τίτλος:
Idiopathic guttate hypomelanosis: An electron microscopy study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Few published data, concerning the electron microscopy findings of idiopathic guttate hypomelanosis have been published so far. Objectives To reveal the electron microscopic findings of idiopathic guttate hypomelanosis and their aetiopathogenetic associations. Methods Punch biopsy specimens from four patients with idiopathic guttate hypomelanosis, after being properly processed, were observed under the electron microscope. Results In the epidermis, melanocytes and melanosomes were normal in structure. In some areas, there was a reduced uptake of melanosomes by the keratinocytes. In the dermis, fibroblasts were structurally normal. Also, most elastic and collagen fibres were normal, but there were focal elastotic changes. Conclusions No significant structural abnormality of the melanocytes was observed, but rather a functional defect in the transfer of melanosomes from the melanocytes to the keratinocytes. © 2014 European Academy of Dermatology and Venereology.
Συγγραφείς:
Kakepis, M.
Havaki, S.
Katoulis, A.
Katsambas, A.
Stavrianeas, N.
Troupis, T.G.
Περιοδικό:
Journal of the European Academy of Dermatology and Venereology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
adult; aged; Article; case report; cell structure; collagen fiber; cytoplasm; dermis; elastic fiber; elastosis; electron microscopy; epidermis; female; fibroblast; human; hypopigmentation; idiopathic guttate hypomelanosis; male; melanocyte; melanosome; priority journal; punch biopsy; biopsy; differential diagnosis; hypopigmentation; keratinocyte; middle aged; pathology; procedures; skin; ultrastructure, Adult; Aged; Biopsy; Diagnosis, Differential; Female; Humans; Hypopigmentation; Keratinocytes; Male; Melanocytes; Microscopy, Electron; Middle Aged; Skin
