Τίτλος:
Myocardial deformation imaging unmasks subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Patients infected by the human immunodeficiency virus (HIV) and receiving highly active antiretroviral therapy have a higher incidence of cardiovascular disease than healthy subjects, but little is known about cardiac function in asymptomatic and treatment-naïve patients. We sought to study cardiac function in asymptomatic HIV-infected, treatment-naïve patients. Methods: We studied 41 HIV-infected and treatment-naïve patients and 20 age- and sex-matched healthy controls. Patients with cardiac symptoms, history of cardiac disease or NT-proBNP >100 pg/mL were excluded. We addressed cardiac function using standard echocardiography along with tissue Doppler (TDI) measurements, including strain/strain rate assessment. Results: Standard echocardiographic parameters did not differ between groups, except for transmitral E wave velocity (64.8 ± 14 cm/s in HIV vs 76.1 ± 10 cm/s in controls, p = 0.002). In contrast, TDI mitral and tricuspid annulus s velocity and all strain/strain rate measurements were significantly lower in HIV patients: s lateral, 10.2 ± 2.4/11.3 ± 0.7, p = 0.011; s septal, 8.1 ± 1.6/8.7 ± 0.8, p = 0.045; s tricuspid, 13.4 ± 2.3/14.9 ± 1.3, p = 0.002; strain/strain rate, septal (strain/strain rate, 15.1 ± 5.7/−0.9 ± 0.3, 25.3 ± 1.7/−1.9 ± 0.2, p < 0.001), anterior (16.7 ± 3/−1.0 ± 0.1, 26.7 ± 1.7/−1.9 ± 0.2, p < 0.001), lateral (16.0 ± 6/−1.0 ± 0.1, 27.5 ± 1.8/−2.2 ± 0.3, p < 0.001) and posterior (15.2 ± 5.8/−1.0 ± 0.2, 26.2 ± 1.8/−2.2 ± 0.3, p < 0.001) left ventricular wall. Conclusions: HIV infection itself is accompanied by subclinical systolic dysfunction, not apparent to standard echocardiography that can be unmasked though using sensitive echocardiographic techniques. © 2015, Springer-Verlag Berlin Heidelberg.
Συγγραφείς:
Karavidas, A.
Xylomenos, G.
Matzaraki, V.
Papoutsidakis, N.
Leventopoulos, G.
Farmakis, D.
Lazaros, G.
Perpinia, A.
Arapi, S.
Paisios, N.
Parissis, J.
Pyrgakis, V.
Gargalianos, P.
Περιοδικό:
Clinical Research in Cardiology
Εκδότης:
Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
Λέξεις-κλειδιά:
adult; Article; cardiomyopathy; clinical article; controlled study; Doppler echography; echocardiography; enzyme linked immunosorbent assay; female; heart function; human; Human immunodeficiency virus infection; left ventricular systolic dysfunction; male; middle aged; risk factor; virus load; Western blotting; complication; computer assisted diagnosis; differential diagnosis; echography; elastography; etiology; heart left ventricle function; Human immunodeficiency virus infection; pathophysiology; procedures; reproducibility; sensitivity and specificity; Young modulus, Adult; Diagnosis, Differential; Elastic Modulus; Elasticity Imaging Techniques; Female; HIV Infections; Humans; Image Interpretation, Computer-Assisted; Male; Reproducibility of Results; Sensitivity and Specificity; Ventricular Dysfunction, Left
DOI:
10.1007/s00392-015-0866-8
