Τίτλος:
Hypoxia-inducible factor-1α (HIF-1α) expression in placentae of women with iron deficiency anemia and β-thalassemia trait
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate hypoxia-inducible factor-1α (HIF-1α) expression in placentae of women with iron-deficiency anemia and β-thalassemia trait and to correlate the results with hematological parameters as well as with parameters associated with the outcome of pregnancy. Methods: About 126 women who delivered in the Larissa University Hospital were divided in three groups: iron-deficiency anemia (n=39), β-thalassemia trait carriers (n=53) and control group (n=34). HIF-1α expression was assessed with immunochemical assays and statistical analysis was performed with chi-squared test and ANOVA. Results: HIF-1α immunostaining was intense in the two groups of anemia. A statistically significant association was found between HIF-1α immunoreactivity and hematocrit (p<0.001), hemoglobin (p<0.001), MCV (p<0.001), transferrin (p<0.001) and its receptors (p=0.040), whereas no significant correlations were observed between HIF-1α, iron serum levels (p=0.256) and ferritin (p=0.232). We found no association between HIF-1α and birthweight (p=0.256), placental weight (p=0.870) and Apgar score at 1′ (p=0.210) and 5′ (p=0.400). Conclusions: HIF-1α expression is affected by anemia, although this factor has no important direct effect on the perinatal outcome. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
Συγγραφείς:
Michalitsi, V.
Dafopoulos, K.
Gourounti, K.
Messini, C.
Ioannou, M.
Christodoulaki, C.
Panagopoulos, P.
Messinis, I.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Εκδότης:
LIBRAPHARM/INFORMA HEALTHCARE
Λέξεις-κλειδιά:
ferritin; hemoglobin; hypoxia inducible factor 1alpha; iron; transferrin; transferrin receptor; HIF1A protein, human; hypoxia inducible factor 1alpha, adult; Apgar score; Article; beta thalassemia; birth weight; controlled study; female; gestational age; hematocrit; hematological parameters; human; human tissue; immunohistochemistry; immunoreactivity; iron blood level; iron deficiency anemia; major clinical study; mean corpuscular volume; newborn hypoxia; placenta; placenta weight; pregnancy outcome; primipara; priority journal; protein expression; tissue section; trophoblast; Western blotting; Anemia, Iron-Deficiency; beta-Thalassemia; case control study; complication; metabolism; pathology; placenta; pregnancy; Pregnancy Complications, Hematologic; young adult, Adult; Anemia, Iron-Deficiency; beta-Thalassemia; Case-Control Studies; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Placenta; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Young Adult
DOI:
10.3109/14767058.2014.921672
