Τίτλος:
Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and −2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (p < 0.05) and MGUS patients (p = 0.001). TTPK was decreased, and WIN/TMSP was increased in both symptomatic and SMM patients compared to MGUS patients (p < 0.05). Symptomatic MM patients had decreased TMSP compared to MGUS patients. The Angp-1/Angp-2 ratio was reduced in symptomatic MM compared to SMM (p = 0.017) and MGUS patients (p < 0.001). TTPK correlated with Angp-1/Angp-2 ratio and importantly with R-ISS. Patients with R-ISS-3 had lower TTPK median value (23 s, range 18–29 s) compared to patients with R-ISS-2 (48 s, range 27–68 s) and patients with R-ISS-1 MM (54 s, range 42–76 s; p ANOVA = 0.01). A subset of patients with low TTPK (lower quartile) had shorter time to progression compared to all other patients. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2. © 2017, Springer-Verlag GmbH Germany.
Συγγραφείς:
Terpos, E.
Matsaridis, D.
Koutoulidis, V.
Zagouri, F.
Christoulas, D.
Fontara, S.
Panourgias, E.
Gavriatopoulou, M.
Kastritis, E.
Dimopoulos, M.A.
Moulopoulos, L.A.
Περιοδικό:
Annals of Hematology
Λέξεις-κλειδιά:
angiopoietin 1; angiopoietin 2; antineoplastic agent; beta 2 microglobulin; bortezomib; contrast medium; creatinine; hemoglobin; lenalidomide; M protein; thalidomide; vasculotropin; angiopoietin 1; angiopoietin 2; ANGPT1 protein, human; ANGPT2 protein, human; tumor protein, adult; aged; angiogenesis; Article; autologous stem cell transplantation; bone disease; cancer prognosis; cancer survival; clinical article; controlled study; creatinine blood level; dynamic contrast-enhanced magnetic resonance imaging; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; human; male; multiple myeloma; overall survival; pelvis; priority journal; prospective study; protein blood level; sensitivity and specificity; thoracolumbar spine; blood; comparative study; diagnostic imaging; middle aged; multiple myeloma; nuclear magnetic resonance imaging; spine; very elderly, Aged; Aged, 80 and over; Angiopoietin-1; Angiopoietin-2; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Myeloma; Neoplasm Proteins; Pelvis; Spine
DOI:
10.1007/s00277-017-3078-7
