Τίτλος:
Chitinase-3-like protein-1 (YKL-40) before and after therapy in supraventricular arrhythmias
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background The inflammatory glycoprotein chitinase-3-like protein 1 or YKL-40 has emerged as a potential biomarker of cardiovascular diseases, including atrial fibrillation (AFib). We sought to assess YKL-40 in a wide spectrum of supraventricular arrhythmias besides AFib in comparison with other inflammatory markers. Methods We determined serum levels of YKL-40, C-reactive protein (CRP) and IL-6 in 70 patients with AFib, atrial flutter, atrioventricular node reentry tachycardia or other supraventricular tachycardias before, immediately after therapy and 1 week after therapy; 20 healthy patients served as controls. Patients were subsequently followed for 6 months for arrhythmia recurrence. Results Baseline YKL-40 was significantly elevated in AFib patients [99.5 (65.5,194)ng/ml versus 47.2 (38.9,51.6)ng/ml in controls, P<0.001], but not in patients with other arrhythmias. YKL-40 levels correlated positively with left atrial volume index (Spearman's rho=0.853, P<0.001). Its levels dropped significantly 1 week posttreatment only in AFib (P=0.009 versus baseline); CRP and IL-6 remained practically stable throughout the study. Arrhythmia recurrence at 6 months occurred in 13 patients (19%), including 11 with AFib and 2 with atrial flutter. Baseline YKL-40 was independently associated with AFib recurrence (adjusted odds ratio=1.02, 95% confidence interval=1.00-1.04, P=0.016). Neither CRP nor IL-6 was associated with AFib recurrence. Conclusion Serum YKL-40 was elevated only in AFib and not in other supraventricular arrhythmias. In AFib, YKL-40 levels were responsive to therapy and predicted long-term recurrence. © 2017 Italian Federation of Cardiology. All rights reserved.
Συγγραφείς:
Michelakakis, N.
Neroutsos, G.J.
Perpinia, A.S.
Farmakis, D.
Voukouti, E.G.
Karavidas, A.J.
Parissis, J.
Georgiakaki, M.T.
Pyrgakis, V.N.
Περιοδικό:
Journal of cardiovascular medicine (Hagerstown, Md.)
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
biological marker; C reactive protein; chitinase 3 like protein 1; interleukin 6; CHI3L1 protein, human; chitinase 3 like protein 1, adult; Article; atrial fibrillation; atrioventricular node reentry tachycardia; cardiovascular parameters; controlled study; correlation analysis; disease association; female; heart atrium flutter; heart supraventricular arrhythmia; human; left atrial volume index; major clinical study; male; pathogenesis; protein blood level; recurrent disease; supraventricular tachycardia; treatment duration; aged; enzymology; heart arrhythmia; metabolism; middle aged, Adult; Aged; Arrhythmias, Cardiac; Chitinase-3-Like Protein 1; Female; Humans; Male; Middle Aged
DOI:
10.2459/JCM.0000000000000539
