Τίτλος:
Vulvar, Perianal and Perineal Cancer after Hidradenitis Suppurativa: A Systematic Review and Pooled Analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
BACKGROUND Hidradenitis suppurativa (HS) is a chronic inflammatory disease that frequently involves the perineal and perianal regions. The association between HS and malignant transformation is a rare but under recognized phenomenon. OBJECTIVE This systematic review aims to summarize all available cases of vulvar and perianal/perineal cancer emerging in patients with HS, describing clinical and therapeutic particularities of these coexisting conditions in female patients. MATERIALS AND METHODS This systematic review and pooled analysis was performed in accordance with the PRISMA guidelines; end-of-search date was June 15, 2015. RESULTS A total of 13 eligible articles were identified; 7 cases of vulvar cancer and 6 cases of perineal/perianal carcinomas in patients with HS were noted. A majority of published cases pertained to rather advanced carcinomas; only occasionally early stage carcinomas were identified. The optimal modifications in the treatment scheme of vulvar, perianal, and perineal cancer in patients with HS have not been established; detailed reporting of recurrence- and survival-related aspects is advised. CONCLUSION Vulvar, perianal, and perineal cancer represent a rare but serious complication of HS. © 2016 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Makris, G.-M.
Poulakaki, N.
Papanota, A.-M.
Kotsifa, E.
Sergentanis, T.N.
Psaltopoulou, T.
Περιοδικό:
Dermatologic Surgery
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
cisplatin; fluorouracil, abdominal cancer; anus carcinoma; cancer combination chemotherapy; cancer localization; cancer radiotherapy; cancer recurrence; cancer staging; cancer surgery; chemosurgery; clinical feature; disease free interval; human; local excision; perineum; priority journal; Review; squamous cell carcinoma; suppurative hidradenitis; systematic review; vulva; vulva carcinoma; buttock; Carcinoma, Squamous Cell; complication; female; pathology; secondary; Skin Neoplasms; suppurative hidradenitis; Vulvar Neoplasms, Buttocks; Carcinoma, Squamous Cell; Female; Hidradenitis Suppurativa; Humans; Perineum; Skin Neoplasms; Vulvar Neoplasms
DOI:
10.1097/DSS.0000000000000944
