Τίτλος:
Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment. Methods and Results: Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102±37pg/mL) were significantly higher (p=0.050) compared to controls. CXCL-1 levels correlated significantly with age (p=0.001) and RRD duration (p=0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C. Conclusions: The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR. © 2014 Informa Healthcare USA, Inc.
Συγγραφείς:
Symeonidis, C.
Androudi, S.
Rotsos, T.
Moschos, M.M.
Souliou, E.
Dimitrakos, S.A.
Diza, E.
Περιοδικό:
Ocular Immunology and Inflammation
Εκδότης:
LIBRAPHARM/INFORMA HEALTHCARE
Λέξεις-κλειδιά:
CXCL1 chemokine; biological marker; CXCL1 chemokine, adult; age; aged; Article; clinical article; clinical feature; controlled study; correlational study; disease course; disease duration; disease severity; female; human; male; middle aged; protein expression; protein function; retina detachment; subretinal fluid; vitreoretinopathy; biosynthesis; complication; enzyme linked immunosorbent assay; follow up; metabolism; Retinal Detachment; subretinal fluid; very elderly; Vitreoretinopathy, Proliferative; young adult, Adult; Aged; Aged, 80 and over; Biological Markers; Chemokine CXCL1; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Middle Aged; Retinal Detachment; Subretinal Fluid; Vitreoretinopathy, Proliferative; Young Adult
DOI:
10.3109/09273948.2013.863942
