Τίτλος:
Serum angiopoietin-2 and CRP levels during COPD exacerbations
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and Objective: Angiopoietin-2 (Ang-2) is an important mediator of angiogenesis and has been implicated in many inflammatory diseases. COPD is characterized by systemic inflammation, which is enhanced during exacerbations and may be assessed by measuring serum C-reactive protein (CRP). The aim of the study was to evaluate serum CRP and Ang-2 levels on the first (D1) and seventh day (D7) of hospitalization due to a COPD exacerbation and to examine possible associations of CRP and Ang-2 levels and kinetics with the length of hospital stay and outcome. Methods: We conducted a prospective study and evaluated 90 patients admitted to the hospital with a diagnosis of an acute exacerbation of COPD. A venous blood sample was obtained from all patients on D1 and D7 of hospitalization, for the measurement of Ang-2 and CRP. Results: Serum Ang-2 levels were significantly higher on D1 compared to D7 during the course of COPD exacerbation (p < 0.001). Serum CRP levels were also significantly higher on D1 compared to D7 (p < 0.001). Serum Ang-2 presented a significant positive correlation with CRP levels both on D1 and D7 (r = 0.315 and r = 0.228, respectively). Patients with unfavorable outcome had significantly higher Ang-2 levels both on D1 (p = 0.04) and D7 (p = 0.01). Conclusions: Serum Ang-2 levels are elevated at the onset of COPD exacerbations and are positively associated with CRP levels. Ang-2 levels decrease during the course of COPD exacerbations in patients with favorable outcome. Serum Ang-2 may serve as a biomarker that could predict the outcome of a COPD exacerbation. © 2014 Informa Healthcare USA, Inc.
Συγγραφείς:
Nikolakopoulou, S.
Hillas, G.
Perrea, D.
Tentolouris, N.
Loukides, S.
Kostikas, K.
Simoes, D.
Georgakopoulou, E.
Vogiatzakis, E.
Veldekis, D.
Bakakos, P.
Περιοδικό:
COPD: Journal of Chronic Obstructive Pulmonary Disease
Λέξεις-κλειδιά:
angiopoietin 2; antibiotic agent; beta 2 adrenergic receptor stimulating agent; C reactive protein; cholinergic receptor blocking agent; prednisolone; steroid; theophylline, aged; antibiotic therapy; arterial gas; article; blood sampling; chronic obstructive lung disease; controlled study; disease association; disease exacerbation; female; hospital admission; hospitalization; human; kinetics; laboratory test; lung function; major clinical study; male; outcome assessment; priority journal; prospective study; protein blood level; venous blood, Aged; Angiopoietin-2; Biological Markers; C-Reactive Protein; Cohort Studies; Disease Progression; Female; Humans; Male; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Spirometry
DOI:
10.3109/15412555.2013.829436
