Τίτλος:
Pure red cell aplasia complicating the course of long-standing mantle cell lymphoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Pure red cell aplasia (PRCA) is a rare cause of severe hypoplastic anemia characterized by profound depletion of erythroid precursors. Although PRCA may be associated with lymphoproliferative diseases, it has never been described in mantle cell lymphoma (MCL). We report what to our knowledge is the first case of a patient with indolent, non-nodal MCL complicated by PRCA. The patient presented with severe hypoproliferative anemia in the setting of a long-standing diagnosis of B-cell chronic lymphocytic leukemia. Bone marrow studies revealed the complete absence of erythroid progenitors. Cyclin D1 positivity on immunohistochemistry, confirmed by a positive FISH for t(11;14) (q13;q32), established the final diagnosis of MCL in conjunction with PRCA. Rituximab monotherapy led to rapid remission of splenomegaly and the leukemic picture, but the patient achieved transfusion independency only with subsequent administration of cyclosporine-A, and remained so during the subsequent 15 months despite the gradual disease recurrence. © The Japanese Society of Hematology 2014.
Συγγραφείς:
Kanellopoulos, A.
Koutsi, K.
Georgiou, G.
Ntalagiorgos, T.
Petevi, K.
Boutsikas, G.
Papageorgiou, L.
Gainaru, G.
Flevari, P.
Angelopoulou, M.K.
Meletis, J.
Vassilakopoulos, T.P.
Περιοδικό:
International Journal of Hematologic Oncology
Εκδότης:
Springer-Verlag Tokyo
Λέξεις-κλειδιά:
clopidogrel; cyclin D1; cyclosporin; cyclosporin A; escitalopram; hemoglobin; hydrochlorothiazide plus valsartan; novel erythropoiesis stimulating protein; rituximab; antineoplastic agent; monoclonal antibody; rituximab, aged; aplastic anemia; article; bone marrow biopsy; case report; chronic lymphatic leukemia; disease duration; eosinophil; erythrocyte; erythrocyte count; erythroid precursor cell; erythropoiesis; female; generalized anxiety disorder; hematocrit; hemoglobin blood level; human; human tissue; hypertension; immunohistochemistry; immunophenotyping; laboratory test; leukocyte count; lymphocytosis; mantle cell lymphoma; mean corpuscular hemoglobin; mean corpuscular volume; medical history; monotherapy; physical examination; pure red cell anemia; recurrent disease; remission; reticulocyte count; splenomegaly; thrombocyte count; transient ischemic attack; treatment duration; very elderly; blood transfusion; bone marrow; complication; computer assisted tomography; Lymphoma, Mantle-Cell; pathology; Red-Cell Aplasia, Pure; splenomegaly; treatment outcome, Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Blood Transfusion; Bone Marrow; Female; Humans; Immunohistochemistry; Immunophenotyping; Lymphoma, Mantle-Cell; Red-Cell Aplasia, Pure; Splenomegaly; Tomography, X-Ray Computed; Treatment Outcome
DOI:
10.1007/s12185-014-1563-5
