Τίτλος:
Effects of testosterone and estradiol on stress-induced adrenal and hippocampal weight changes in female rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To examine the impact of circulating testosterone (T) and the T/Estradiol (T/ Ediol) ratio on chronic stress-induced changes of adrenal and hippocampal weight during proestrus (PE) and estrus (E) in female rats. Design: Stress was composed of repeated vaginal smear screening (VSS) and measured by the emotional reactivity score (ERS). Adrenal and hippocampal weight and the T, Ediol and T/Ediol ratio were assessed in PE and E controls as well as 20 h after sham or left adrenalectomy performed on diestrus-2 (DE-2) and PE, respectively. T was measured in ovariectomized (OVX) rats treated with estradiol benzoate (EB) or vehicle (VEH) and in non-OVX EB-treated rats. Results: In OVX rats EB treatment increased adrenal weight and T levels. After separation of VEH- and EB-treated rats into the low and high T-range (below and above the mean, respectively), it was observed that higher T was accompanied by higher adrenal weight in EB- compared to VEH-treated rats only in the low T-range. Non-OVX EB-treated rats with high T had lower adrenal weight compared to low T. Cycling rats assigned to the high T-range presented higher T/Ediol ratio but similar ERS and Ediol levels compared to rats in the low T-range, and were characterized by reduced adrenal weight, higher hippocampal weight and prevalence of PE versus E. Conclusions: High T and high T/Ediol ratios are prominent in PE compared to E and exert a protective effect on hippocampal neuronal degeneration after similar chronic stress through T-mediated lessening of stress response thus counteracting the stress-promoting effects of Ediol.
Συγγραφείς:
Sfikakis, A.
Pitychoutis, P.M.
Tsouma, A.
Messari, I.
Papadopoulou-Daifoti, Z.
Περιοδικό:
Vitamins and Hormones
Εκδότης:
Hellenic Endocrine Society
Λέξεις-κλειδιά:
estradiol; estradiol benzoate; testosterone; estradiol; testosterone, adrenal gland; animal experiment; animal tissue; article; chronic stress; controlled study; emotional reactivity score; emotional stress; estrus; female; hippocampus; hormone action; nonhuman; organ weight; ovariectomy; prevalence; proestrus; radioimmunoassay; rat; scoring system; testosterone blood level; thymus; vagina smear; adrenal gland; adrenalectomy; animal; drug effects; hippocampus; mental stress; organ size; pathology; Wistar rat, Adrenal Glands; Adrenalectomy; Animals; Estradiol; Female; Hippocampus; Organ Size; Ovariectomy; Rats; Rats, Wistar; Stress, Psychological; Testosterone
