Τίτλος:
International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: The EORTC QLQ-CML24
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ C30. Patients and methods: The process followed a predefined and systematic stepwise iterative process as defined by the EORTC guidelines for questionnaire development. The process was divided into 3 phases: (1) generation of relevant HRQOL issues, (2) operationalization of the HRQOL issues into a set of items, and (3) pretesting the questionnaire for relevance and acceptability. Descriptive statistics and psychometric analyses were also performed. Results: Overall, 655 CML patients were enrolled in 10 countries including the USA and countries in Europe and Asia. Interviews with health-care professionals experienced in CML (n = 59) were also conducted. Results from the interviews, clinical experiences, and statistical analyses were used to develop the EORTC QLQ-CML24. The final module consists of 24 items assessing the following aspects: symptom burden, impact on daily life and on worry/mood, body image problems, and satisfaction with care and with social life. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.73 to 0.83 for the proposed scales. Conclusion: The EORTC QLQ-CML24 is an internationally developed HRQOL questionnaire for CML patients, and its implementation in clinical research and practice can provide important information to facilitate clinical decision-making. © 2013 Springer Science+Business Media Dordrecht.
Συγγραφείς:
Efficace, F.
Baccarani, M.
Breccia, M.
Saussele, S.
Abel, G.
Caocci, G.
Guilhot, F.
Cocks, K.
Naeem, A.
Sprangers, M.
Oerlemans, S.
Chie, W.
Castagnetti, F.
Bombaci, F.
Sharf, G.
Cardoni, A.
Noens, L.
Pallua, S.
Salvucci, M.
Nicolatou-Galitis, O.
Rosti, G.
Mandelli, F.
Περιοδικό:
Quality of Life Research
Εκδότης:
Kluwer Academic Publishers
Λέξεις-κλειδιά:
benzamide derivative; imatinib; piperazine derivative; protein kinase inhibitor; pyrimidine derivative, adult; aged; article; chronic myeloid leukemia; demography; equipment; female; health status indicator; human; international cooperation; interview; Karnofsky Performance Status; male; middle aged; multicenter study; psychological aspect; psychometry; quality of life; questionnaire; social class; standard; very elderly; young adult, Adult; Aged; Aged, 80 and over; Benzamides; Female; Health Status Indicators; Humans; International Cooperation; Interviews as Topic; Karnofsky Performance Status; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Protein Kinase Inhibitors; Psychometrics; Pyrimidines; Quality of Life; Questionnaires; Residence Characteristics; Social Class; Young Adult
DOI:
10.1007/s11136-013-0523-5
