Τίτλος:
Associations of placental weight with maternal and cord blood hormones
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Placental weight has been associated with mammographic pattern and coronary heart disease in the adult offspring, but the mechanisms are unknown. We evaluated the associations of maternal and cord blood hormones with placental weight in normal pregnancies. Methods: Prospective study of 167 normal singleton pregnancies in Boston, USA and 256 in Shanghai, China. Maternal hormone levels at the 27th gestational week were available for all pregnancies. Cord blood measurements were available for 86 pregnancies in Boston and 104 in Shanghai. Pearson partial correlation coefficients of log-transformed hormone levels with placental weight were calculated. Results: Maternal levels of estriol, testosterone, and progesterone (P < .05) were positively associated with placental weight. There was no such evidence for adiponectin, prolactin, and insulin-like growth factor (IGF)-I. Cord blood steroids tended to be inversely associated with placental weight, the results being statistically significant for testosterone (P < .05). There was a marginally significant positive association of cord blood IGF-I with placental weight. Reported results were adjusted for study center. Conclusions: Placental weight appears to be positively correlated with maternal steroids. Its correlation with cord blood steroids, however, appears inverse, compatible with negative feedback mechanisms. There is also a suggestion for placental weight to be positively associated with cord blood IGF-I. © 2013 Elsevier Inc.
Συγγραφείς:
Lagiou, P.
Hsieh, C.-C.
Samoli, E.
Lagiou, A.
Xu, B.
Yu, G.-P.
Onoyama, S.
Chie, L.
Vatten, L.J.
Adami, H.-O.
Trichopoulos, D.
Williams, M.A.
Περιοδικό:
ANNALS OF EPIDEMIOLOGY
Λέξεις-κλειδιά:
adiponectin; estradiol; estriol; hormone; progesterone; prolactin; sex hormone binding globulin; somatomedin B; somatomedin binding protein 3; somatomedin C; testosterone, adult; article; China; correlational study; estradiol blood level; estriol blood level; female; human; major clinical study; maternal blood; placenta weight; priority journal; progesterone blood level; prolactin blood level; prospective study; protein blood level; testosterone blood level; umbilical cord blood; United States, Hormones; Insulin-like growth factor; Intrauterine growth; Placenta, Adult; Boston; China; Female; Fetal Blood; Gestational Age; Gonadal Steroid Hormones; Humans; Insulin-Like Growth Factor Binding Protein 3; Organ Size; Placenta; Pregnancy; Prospective Studies; Sex Hormone-Binding Globulin; Somatomedins; United States
DOI:
10.1016/j.annepidem.2013.08.003
