Τίτλος:
Cardiovascular disease in childhood: The role of obesity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In recent years, childhood obesity is becoming an epidemic health problem. It is now evident from many studies that childhood obesity is correlated with adult excess weight status and the development of risk factors for cardiovascular diseases in adulthood, including hypertension, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome. The exposure to obesity and to the above risk factors during childhood subsequently lead to atherosclerotic development, such as altered vascular structure and function, although the mechanisms are still unclear. Several non-invasive, and thus easy-to-obtain measures of arterial structure and function, have been shown to be clinically useful in providing information about vasculature early in the course of atherosclerosis, including measurement of endothelial function, carotid intima media thickness, and arterial stiffness. The early detection of cardiovascular abnormalities is essential because the control of the atherogenic process is more effective during its early stages. The present review focuses on the cardiovascular consequences of obesity, on the mechanisms and the methods of measurement of endothelial dysfunction in obese children and adolescents, and on the ways of intervention for the improvement of vascular health. © 2013 Springer-Verlag Berlin Heidelberg.
Συγγραφείς:
Herouvi, D.
Karanasios, E.
Karayianni, C.
Karavanaki, K.
Περιοδικό:
European Journal of Pediatrics
Λέξεις-κλειδιά:
adiponectin; angiotensinogen; cholesterol; ghrelin; glucose; high density lipoprotein cholesterol; insulin; interleukin 6; low density lipoprotein cholesterol; resistin; triacylglycerol; tumor necrosis factor alpha, arterial stiffness; arterial wall thickness; cardiovascular disease; cardiovascular risk; cerebrovascular accident; childhood disease; childhood obesity; congenital heart disease; coronary artery atherosclerosis; dyslipidemia; endothelial dysfunction; exercise; fetal malnutrition; heart infarction; high birth weight; human; hypertension; impaired glucose tolerance; insulin resistance; lifestyle modification; metabolic syndrome X; non insulin dependent diabetes mellitus; priority journal; review; weight gain, Adiposity; Cardiovascular Diseases; Child; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Life Style; Metabolic Syndrome X; Pediatric Obesity; Risk Factors; Weight Gain; Weight Reduction Programs
DOI:
10.1007/s00431-013-1932-8
