Τίτλος:
Cord blood chemerin and obestatin levels in large for gestational age infants
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate possible alterations in cord blood levels of adipokines, chemerin and obestatin (secreted by adipose tissue and associated with later development of insulin resistance/metabolic syndrome), as well as insulin, in large for gestational age (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms. Methods: Cord blood chemerin, obestatin, and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from nondiabetic mothers) and 40 AGA singleton full-term infants. Results: Cord blood chemerin concentrations were significantly higher in LGA compared with AGA neonates (b = 38.91, SE 9.29, p < 0.001). In contrast, no significant differences in obestatin concentrations were observed between groups. Insulin levels were significantly elevated as customized centiles increased (b = 0.003, SE = 0.001, p = 0.032). Conclusions: Higher chemerin concentrations in LGA neonates possibly reflect the increased adipose tissue in this group. Lack of difference between the two groups in circulating levels of obestatin-possibly a sensitive marker of insulin resistance-might be due to development of metabolic disorders later in life. © 2013 Informa UK, Ltd.
Συγγραφείς:
Boutsikou, T.
Briana, D.D.
Boutsikou, M.
Kafalidis, G.
Stamati, L.
Baka, S.
Hassiakos, D.
Gourgiotis, D.
Malamitsi-Puchner, A.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Λέξεις-κλειδιά:
chemerin; insulin; obestatin, adipose tissue; article; blood analysis; body fat; disease association; disease marker; human; insulin blood level; insulin resistance; large for gestational age; metabolic syndrome X; priority journal; protein blood level; protein secretion; umbilical cord blood, Adult; Birth Weight; Chemokines; Female; Fetal Blood; Ghrelin; Humans; Infant, Newborn; Insulin; Male; Pregnancy
DOI:
10.3109/14767058.2012.728648
