Τίτλος:
Continuation of smoking after treatment of laryngeal cancer: An independent prognostic factor?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: The aim of the study is to examine if continuation of smoking after treatment is an independent factor affecting the prognosis of laryngeal cancer. Materials and Methods: A total of 153 patients met the inclusion criteria for this prospective study, and they were followed up for 12-60 months. Smoking cessation/continuation rates were recorded and associated with disease recurrence and overall patient survival. Results: The recurrence rate was 35.29%. Twenty-five percent of the patients continued smoking after treatment, 75% stopped. Of the patients who quit smoking, 28.69% died during the follow-up period, compared to 52.63% of those who continued (p = 0.0047). The respective recurrence rates were 28.7 and 55.26% (p = 0.0022). A stepwise multivariate Cox regression analysis eliminated potential confounders regarding the overall survival rate and confirmed that time between symptom onset and diagnosis, T and N stage and continuation of smoking after treatment are statistically significant factors. Among them, continuation of smoking was found to have the strongest correlation to the overall survival rate. Conclusion: Continuation of smoking after treatment of laryngeal cancer is an independent negative prognostic factor. From a clinical standpoint, all patients with known laryngeal cancer should be strongly encouraged to quit smoking. Copyright © 2012 S. Karger AG, Basel.
Συγγραφείς:
Kikidis, D.
Vlastarakos, P.V.
Manolopoulos, L.
Yiotakis, I.
Λέξεις-κλειδιά:
adult; aged; article; cancer prognosis; cancer recurrence; cancer staging; controlled study; death; female; follow up; human; laryngectomy; larynx cancer; major clinical study; male; overall survival; priority journal; prospective study; smoking; smoking cessation; survival rate, Adult; Aged; Carcinoma; Female; Follow-Up Studies; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Prospective Studies; Risk Factors; Smoking; Smoking Cessation; Survival Rate
