Τίτλος:
Physiological renal regenerating medicine in VLBW preterm infants: Could a dream come true
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
An emerging hypothesis from the recent literature explain how specific adverse factors related with growth retardation as well as of low birth weight (LBW) might influence renal development during fetal life and then the insurgence of hypertension and renal disease in adulthood. In this article, after introducing a brief overview of human nephrogenesis, the most important factors influencing nephron number at birth will be reviewed, focusing on the in utero experiences that lead to an increased risk of developing hypertension and/or kidney disease in adult. Since nephrogenesis in preterm human newborns does not stop at birth, but it continues for 46 weeks postnatally, a better knowledge of the mechanisms able to accelerate nephrogenesis in the perinatal period, could represent a powerful tool in the hands of neonatologists. We suggest to define this approach to a possible therapy of a deficient nephrogenesis at birth physiological renal regenerating medicine. Our goal in preterm infants, especially VLBW, could be to prolong the nephrogenesis not only for 6 weeks after birth but until 36 weeks of post conceptual age, allowing newborn kidneys to restore their nephron endowment, escaping susceptibility to hypertension and to renal disease later in life. © 2012 Informa UK, Ltd.
Συγγραφείς:
Fanni, D.
Gerosa, C.
Nemolato, S.
Mocci, C.
Pichiri, G.
Coni, P.
Congiu, T.
Piludu, M.
Piras, M.
Fraschini, M.
Zaffanello, M.
Iacovidou, N.
Van Eyken, P.
Monga, G.
Faa, G.
Fanos, V.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Αριθμός / τεύχος:
SUPPL. 3
Λέξεις-κλειδιά:
birth; cell count; DNA methylation; epigenetics; gestation period; high risk infant; high risk patient; human; hypertension; intrauterine growth retardation; kidney development; kidney disease; kidney parenchyma; medical information; molecular biology; nephron; nonhuman; perinatal care; prematurity; priority journal; renal regeneration; review; tissue regeneration; very low birth weight, Animals; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Kidney Diseases; Nephrons
DOI:
10.3109/14767058.2012.712339
