Τίτλος:
Management of cutaneous T-Cell lymphoma patients with extracorporeal photopheresis. The hellenic experience
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Extracorporeal photopheresis (ECP) is an established therapy for cutaneous T-cell lymphoma (CTCL). The objective of this study was to further explore the clinical efficacy of ECP combined with immunomodulatory agents.Eighteen patients with histologically proven CTCL were followed-up after therapy with ECP, mainly combined with interferon-α or bexarotene.A total of 61% of patients responded to therapy (n=11; CR: 5, PR: 6). Median survival was 51. months, progression free survival was 28. months and response duration was 29±23.9. months.ECP combined therapy was highly effective or had a palliative effect in CTCL resistant to previous treatments. © 2011.
Συγγραφείς:
Siakantaris, M.P.
Tsirigotis, P.
Stavroyianni, N.
Argyropoulos, K.V.
Girkas, K.
Pappa, V.
Chondropoulos, S.
Papadavid, E.
Sakellari, I.
Anagnostopoulos, A.
Antoniou, C.
Dervenoulas, J.
Περιοδικό:
Transfusion and Apheresis Science
Λέξεις-κλειδιά:
alpha interferon; bexarotene; denileukin diftitox; pentostatin, adult; aged; article; cancer survival; clinical article; clinical trial; cutaneous T cell lymphoma; extracorporeal photopheresis; female; follow up; human; male; progression free survival; PUVA; survival time; treatment outcome; treatment response, Adult; Aged; Disease-Free Survival; Female; Follow-Up Studies; Humans; Immunologic Factors; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Photopheresis; Skin Neoplasms; Survival Rate
DOI:
10.1016/j.transci.2011.10.029
