Τίτλος:
Clinicopathological characteristics of ovarian carcinomas associated with endometriosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction Substantial histopathology data provide evidence that endometriosis might be viewed as a precursor lesion of endometrioid and clear cell carcinoma of the ovary, via intermediary atypical borderline lesions. Also, genes involved in both endometriosis and epithelial ovarian cancer have been shown to play a role in the pathogenesis of endometriosis-associated ovarian carcinoma. Material and methods A retrospective study of 17 cases of ovarian carcinomas associated with endometriosis, diagnosed between 2000 and 2009, at Aretaieion Hospital of University of Athens, is presented. 10/17 cases in this study (58.8%) were clear cell carcinomas (CCC), 6/17 cases (35.3%) were endometrioid adenocarcinomas (EAC) and 1/17 cases (5.9%) was a serous carcinoma associated with ovarian endometriosis. Patients's age was 27-76 years (mean age 58 years). Typical ovarian endometriosis was documented in 8/17 (47%) of the tumors. In 9/17 cases, areas of fibrosis or cystic lesions infiltrated by iron-laden macrophages and endometrial-like stroma, consistent with endometriosis, were observed. Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. © 2011 Springer-Verlag.
Συγγραφείς:
Kondi-Pafiti, A.
Papakonstantinou, E.
Iavazzo, C.
Grigoriadis, C.
Salakos, N.
Gregoriou, O.
Περιοδικό:
Archives of Gynecology and Obstetrics
Λέξεις-κλειδιά:
carboplatin; paclitaxel, adult; aged; article; carcinogenesis; clear cell carcinoma; clinical article; clinical feature; cyst; cytoreductive surgery; endometrioid carcinoma; endometriosis; female; fibrosis; genetic association; Greece; histopathology; human; hysterectomy; lymphadenectomy; macrophage; omentectomy; ovary carcinoma; peritoneal biopsy; postoperative care; retrospective study; salpingooophorectomy; stroma; treatment planning; university hospital, Adenocarcinoma, Clear Cell; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Endometrioid; Chemotherapy, Adjuvant; Endometriosis; Female; Humans; Hysterectomy; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Ovariectomy; Paclitaxel; Retrospective Studies; Salpingectomy
DOI:
10.1007/s00404-011-1957-z
