Τίτλος:
Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Platelet-activating factor (PAF), a mediator of proatherosclerotic inflammatory processes, is also implicated in endothelial dysfunction during human immunodeficiency virus (HIV) infection. We examined PAF metabolism in blood of naive male patients, 8 with early HIV infection (group A) and 17 just before treatment initiation (group B), versus 18 healthy age-matched males (group C). Statistical analysis was performed with 1-way analysis of variance (ANOVA) criterion and Pearson r test. Higher PAF biosynthesis in patients' leukocytes versus group C was accompanied by an increase in lipoprotein- associated phospholipase A2 (Lp-PLA2) activity that degrades PAF. Moreover, PAF synthesis was higher and Lp-PLA2 activity was lower in group B compared to group A. Lipoprotein-associated phospholipase A2 was positively correlated with viral load and negatively correlated with CD4 cell counts in group B. The activities of PAF-basic biosynthetic enzymes in patients' leukocytes were also negatively correlated with CD4 cell counts. The observed continuous increase in PAF biosynthesis during HIV infection progress seems to amplify the risk of AIDS manifestations and/or cardiovascular complications in HIV-infected patients, while a subsequent increase in Lp-PLA2 activity seems to be a host response. © 2012 The Author(s).
Συγγραφείς:
Tsoupras, A.B.
Chini, M.
Mangafas, N.
Tsogas, N.
Stamatakis, G.
Tsantila, N.
Fragopoulou, E.
Antonopoulou, S.
Gargalianos, P.
Demopoulos, C.A.
Lazanas, M.C.
Περιοδικό:
International Angiology
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
1 o alkylglycero 3 phosphorylcholine; acetyl coenzyme A acetyltransferase; cholinephosphotransferase; lipoprotein; phospholipase A2; thrombocyte activating factor, adult; article; blood analysis; cardiovascular disease; CD4 lymphocyte count; clinical article; comparative study; controlled study; disease course; enzyme activity; highly active antiretroviral therapy; host susceptibility; human; human cell; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; human tissue; in vivo study; leukocyte; male; protein blood level; protein degradation; protein metabolism; protein synthesis; risk factor; symptom; virus load
DOI:
10.1177/0003319711420608
