Τίτλος:
A diet rich in monounsaturated fatty acids improves the lipid profile of mice previously on a diet rich in saturated fatty acids
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This study investigated whether switching from a diet rich in saturated fatty acids (SAFAs) to a diet rich in monounsaturated fatty acids (MUFAs) or to one with equal amounts of MUFAs-SAFAs favorably affects the lipid profile of hypercholesterolemic mice. C57BL/6 mice (n = 82) were allocated into 4 groups. The first group (control, n = 10) was fed standard chow. The 3 remaining groups (n = 24 mice/group) were fed a SAFA-rich diet for 8 weeks and were then allocated for 16 weeks to either a MUFA-rich diet, an equal in MUFAs-SAFAs-rich diet, or continued the previous SAFA-rich diet. After 8 weeks, mice consuming SAFA-rich diet had increased weight, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels (P <.05 vs baseline). At week 24, MUFA-rich and MUFA-SAFA rich diets decreased TC and low-density lipoprotein cholesterol (LDL-C) levels (P <.05) compared with week 8. In conclusion, switching to MUFA-rich diets or substituting half of the SAFAs with MUFAs can reverse diet-induced-hypercholesterolemia. © SAGE Publications 2011.
Συγγραφείς:
Arapostathi, C.
Tzanetakou, I.P.
Kokkinos, A.D.
Tentolouris, N.K.
Vlachos, I.S.
Donta, I.A.
Perrea, K.N.
Perrea, D.N.
Katsilambros, N.L.
Περιοδικό:
International Angiology
Λέξεις-κλειδιά:
cholesterol; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; monounsaturated fatty acid; saturated fatty acid; triacylglycerol, animal model; article; cholesterol blood level; diet therapy; hypercholesterolemia; lipid diet; lipoprotein blood level; male; mouse; nonhuman; response time; treatment duration; triacylglycerol blood level; weight gain, Animals; Dietary Fats; Disease Models, Animal; Fatty Acids; Fatty Acids, Monounsaturated; Hypercholesterolemia; Lipids; Male; Mice; Mice, Inbred C57BL; Treatment Outcome
DOI:
10.1177/0003319711403734
