Τίτλος:
Liver hypertrophy after percutaneous portal vein embolization: Comparison of N-butyl-2-cyanocrylate versus sodium acrylate-vinyl alcohol copolymer particles in a swine model
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose Percutaneous portal vein embolization (PPVE) induces hypertrophy of the future liver remnant before hepatic resection. The ideal embolic material has not yet been determined. We compared N-butyl-2-cyanocrylate (NBCA) with sodium acrylate-vinyl alcohol copolymer particles using a swine model. Materials and Methods Twelve pigs underwent PPVE. Six pigs (group A) were embolized with NBCA, and 6 pigs (group B) were embolized with sodium acrylate-vinyl alcohol copolymer particles. Computed tomographic volumetry of the embolized lobe (EL) and the nonembolized lobe (NEL), along with liver function tests, was performed before and at 14 and 28 days after embolization. Tissue samples from both lobes were taken 14 and 28 days after PPVE. Results NEL-volume and NEL-ratio increases were significantly higher in group A at 14 and 28 days after PPVE (78 and 52% and 91 and 66%, respectively) than in group B (32 and 12% and 28 and 10%, respectively) (p\0.05). Percent change of the EL-volume was significantly higher for group A at 28 days after PPVE. No statistically significant difference was found between the groups regarding hepatocyte proliferation on the NEL and apoptosis on the EL at both time intervals. Conclusion PPVE using NBCA is more efficient and causes more NEL hypertrophy than microspheres. © 2010 Springer Science+Business Media, LLC.
Συγγραφείς:
Tsoumakidou, G.
Theocharis, S.
Ptohis, N.
Alexopoulou, E.
Mantziaras, G.
Kelekis, N.L.
Brountzos, E.N.
Περιοδικό:
CardioVascular and Interventional Radiology
Λέξεις-κλειδιά:
alanine aminotransferase; aspartate aminotransferase; bilirubin; copolymer; cyanoacrylate derivative; gamma glutamyltransferase; n butyl 2 cyanocrylate; sodium arcylate vinyl alcohol copolymer; unclassified drug, alanine aminotransferase blood level; animal experiment; animal tissue; apoptosis; article; artificial embolism; aspartate aminotransferase blood level; bilirubin blood level; cell proliferation; computer assisted tomography; controlled study; gamma glutamyl transferase blood level; Kupffer cell; liver cell; liver hypertrophy; male; nonhuman; priority journal; swine, Acrylic Resins; Angiography, Digital Subtraction; Animals; Embolization, Therapeutic; Enbucrilate; Hypertrophy; Liver; Male; Microspheres; Polyvinyls; Portal Vein; Sus scrofa; Tissue Adhesives; Tomography, X-Ray Computed
DOI:
10.1007/s00270-010-0046-1
