Τίτλος:
A review on radiotherapy hypofractionation schedules for breast cancer treatment
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Radiation therapy is an integral part of management in breast carcinoma treatment. Standard curative schedules of radiotherapy to the breast deliver 25 fractions of 2.0 Gy per day over 5-6 weeks. Considerable recent literature suggests that hypo-fractionation may be advisory in breast cancer. The use of fewer fractions of more than 2 Gy per day (hypo-fractionation) is based on data suggesting that breast carcinoma is more sensitive to fraction size than squamous carcinomas and therefore could have similar fractionation sensitivity to the dose-limiting healthy tissues, including skin, subcutaneous tissues, muscle and ribs. In this article, a review of published studies and currently ongoing trials, which may provide evidence for the use of hypo-fractionated radiotherapy in breast cancer patients, is presented. Also, for all these different hypo-fractionation regimens found in literature, biologically effective dose (BED) values are calculated and compared. Data from studies and randomised trials seem to support the concept that modest hypo-fractionation can be used to treat the whole breast after breast-conserving surgery with similar rates of local control and radiation morbidity as seen with conventional fractionation. © Copyright Cambridge University Press 2011.
Συγγραφείς:
Armpilia, C.
Antypas, C.
Zygogianni, A.
Balafouta, M.
Sandilos, P.
Kouvaris, J.
Περιοδικό:
Journal of Radiotherapy in Practice
Λέξεις-κλειδιά:
breast cancer; cancer control; cancer patient; cancer radiotherapy; controlled study; human; morbidity; partial mastectomy; prospective study; quality of life; radiation dose; radiation dose fractionation; radiosensitivity; randomized controlled trial; review; squamous cell carcinoma
DOI:
10.1017/S1460396910000294
