Τίτλος:
Urinary interleukin-6 (IL-6) and transforming growth factor (TGF-β) levels in corticosteroidtreated patients with IgA nephropathy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) are implicated in the progression of IgA nephropathy, which is usually treated with corticosteroids. Patients and methods: Urinary IL-6 and TGF-β were measured in 21 proteinuric patients with IgA nephropathy, before and after treatment with corticosteroids, to estimate the activity of the disease after remission of proteinuria. Results: Urinary IL-6 and TGF-β levels at diagnosis were significantly higher in patients with IgA nephropathy compared to healthy subjects. TGF-β levels, were significantly higher in patients with proteinuria > 1 g/24 h and/or severe mesangial proliferation. Although a significant reduction of proteinuria was observed with corticosteroid treatment, urinary IL-6 and TGF-β levels remained elevated. Deterioration of renal function over a period of 5 years was observed in 3 patients. High urinary IL-6 levels at diagnosis represent a significant parameter distinguishing patients with progressive course in comparison to those with favorable clinical outcome (p = 0.01). Conclusion: Treatment of patients with IgA nephropathy with corticosteroids is followed by remission of proteinuria but still increased urinary IL-6 and TGF-β excretion. This may be related to an ongoing inflammatory process within the kidney, and further research is required to estimate the value of urinary IL-6 and TGF-β as markers of activity of the disease. © 2011 Dustri-Verlag Dr. K. Feistle.
Συγγραφείς:
Kalliakmani, P.
Nakopoulou, L.
Tsakas, S.
Gerolymos, M.
Papasotiriou, M.
Goumenos, D.S.
Περιοδικό:
Clinical Nephrology
Λέξεις-κλειδιά:
dipeptidyl carboxypeptidase inhibitor; interleukin 6; prednisone; transforming growth factor beta, adult; article; cell proliferation; clinical article; controlled study; corticosteroid therapy; disease activity; female; human; immunoglobulin A nephropathy; kidney dysfunction; male; mesangium cell; protein urine level; proteinuria; remission, Adolescent; Adrenal Cortex Hormones; Adult; Enzyme-Linked Immunosorbent Assay; Female; Glomerulonephritis, IGA; Humans; Interleukin-6; Kidney; Kidney Function Tests; Male; Middle Aged; Proteinuria; Transforming Growth Factor beta; Treatment Outcome; Young Adult
