Τίτλος:
Epidemiology, risk factors for and outcome of candidaemia among non-neutropenic patients in a Greek intensive care unit
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To determine the epidemiology, risk factors for and outcome of candidaemia in critically ill patients, a matched case-control study was performed in a 25-bed intensive care unit (ICU) from August 2004 to January 2006. Candidaemia occurred in 33 patients; each patient was matched to four controls according to admission illness severity, diagnostic category and length of ICU stay. Candida non-albicans species predominated (67.7%). The presence of acute respiratory distress syndrome (ARDS) was the only independent risk factor for candidaemia development (OR, 2.93; 95% CI 1.09-7.81, P=0.032). Mortality was 60.6% among patients with candidaemia and 22% among controls (P<0.001). The presence of candidaemia (OR, 9.37; 95% CI 3.48-25.26, P<0.001) and the illness severity on admission (acute physiologic and chronic health evaluation II score, OR, 1.17; 95% CI 1.12-1.24, P<0.001) were independently associated with mortality. Among candidaemic patients, risk factors for mortality were the severity of organ dysfunction (sequential organ failure assessment score, OR, 1.57; 95% CI 1.00-2.46, P=0.05) and a low serum albumin level (OR, 0.74; 95% CI 0.59-0.94, P=0.012) both of them occurred on candidaemia onset. We conclude that in critically ill patients matched for illness severity and length of ICU stay, the only independent risk factor for candidaemia was the presence of ARDS. Mortality was independently associated with acquisition of candidaemia and with the illness severity at candidaemia onset. © 2009 Blackwell Verlag GmbH.
Συγγραφείς:
Pratikaki, M.
Platsouka, E.
Sotiropoulou, C.
Douka, E.
Paramythiotou, E.
Kaltsas, P.
Kotanidou, A.
Paniara, O.
Roussos, C.
Routsi, C.
Λέξεις-κλειδιά:
albumin; aminoglycoside; amphotericin B; antifungal agent; beta lactam; carbapenem; cephalosporin; colistin; fluconazole; flucytosine; glycopeptide; itraconazole; metronidazole; oxazolidinone derivative; quinolone; voriconazole, adult respiratory distress syndrome; albumin blood level; APACHE; article; Candida; candidemia; case control study; clinical article; controlled study; disease severity; female; human; intensive care unit; length of stay; male; mortality; multiple organ failure; nonhuman; priority journal; risk factor, Adult; Aged; Aged, 80 and over; Antifungal Agents; Candidemia; Case-Control Studies; Critical Illness; Cross Infection; Female; Greece; Humans; Intensive Care Units; Male; Middle Aged; Prospective Studies; Risk Factors; Treatment Outcome, Candida
DOI:
10.1111/j.1439-0507.2009.01787.x
