Τίτλος:
Maternal and fetal circulating sKL and ET-1 levels as function of normal labor at term
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives. To determine whether labor is associated with alterations of the levels of soluble c-kit ligand (sKL) and endothelin-1 (ET-1) in maternal plasma and umbilical cord blood. Methods. The sKL and ET-1 levels were investigated in umbilical cord and maternal plasma on the day of delivery in 18 pregnant women with vaginal delivery during labor, 18 non-pregnant women and 9 pregnant women before cesarean delivery, using an ELISA assay. Results. Umbilical cord plasma sKL levels were significantly higher than the maternal plasma in both types of delivery (p=0.0001, p<0.0001, respectively). However, maternal plasma ET-1 levels in the presence of labor were significantly higher than the cesarean delivery group (p<0.0001). No difference was noted for sKL and ET-1 in umbilical cord vessels of both groups. Furthermore, a highly significant inverse correlation was documented between the individual levels of cord plasma ET-1 and the levels of cord plasma sKL (r=-0.6269, p=0.0054). Conclusions. The sKL levels found in umbilical cord plasma are consistent with the pleiotropic effects of sKL in facilitating the transition of the fetus to the neonatal stage. The reduced ET-1 maternal plasma levels, compared to non-pregnant women, probably are indicative of a putative mechanism for embryo protection from vasoconstriction sequelae. This assumption is strengthened by the corresponding ET-1 levels in umbilical cord plasma. © 2011 Informa UK, Ltd.
Συγγραφείς:
Pappa, K.I.
Anagnou, N.P.
Daskalakis, G.
Ioannides, I.
Angelidou, K.
Antsaklis, A.
Περιοδικό:
Journal of Maternal-Fetal and Neonatal Medicine
Λέξεις-κλειδιά:
endothelin 1; stem cell factor, adult; article; cesarean section; controlled study; cytokine production; enzyme linked immunosorbent assay; female; fetus; fetus circulation; human; human experiment; labor onset; maternal plasma; mother fetus relationship; newborn period; pleiotropy; priority journal; protein blood level; protein function; third trimester pregnancy; umbilical cord blood flow; vaginal delivery, Adult; Case-Control Studies; Endothelin-1; Female; Fetal Blood; Fetus; Health; Humans; Labor, Obstetric; Mothers; Placental Circulation; Pregnancy; Solubility; Stem Cell Factor; Term Birth; Young Adult
DOI:
10.3109/14767058.2010.496502
