Περίληψη:
This study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24. h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT ≤0.12. ng/mL but 19.9% in those with PCT >0.12. ng/mL [. P< 0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT ≤0.85. ng/mL but 45.3% in those with PCT >0.85. ng/mL (P = 0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission. © 2010 The Hospital Infection Society.
Συγγραφείς:
Giamarellos-Bourboulis, E.J.
Tsangaris, I.
Kanni, Th.
Mouktaroudi, M.
Pantelidou, I.
Adamis, G.
Atmatzidis, S.
Chrisofos, M.
Evangelopoulou, V.
Frantzeskaki, F.
Giannopoulos, P.
Giannikopoulos, G.
Gialvalis, D.
Gourgoulis, G.M.
Kotzampassi, K.
Katsifa, K.
Kofinas, G.
Kontopidou, F.
Koratzanis, G.
Koulouras, V.
Koutsikou, A.
Koupetori, M.
Kritselis, I.
Leonidou, L.
Mega, A.
Mylona, V.
Nikolaou, H.
Orfanos, S.
Panagopoulos, P.
Paramythiotou, E.
Papadopoulos, A.
Papanikolaou, X.
Pavlaki, M.
Polychronopoulos, V.
Skoutelis, A.
Theodotou, A.
Vassiliaghou, M.
Douzinas, E.E.
Gogos, C.
Armaganidis, A.
Λέξεις-κλειδιά:
procalcitonin, adult; aged; article; clinical trial; diagnostic value; double blind procedure; female; human; intensive care unit; major clinical study; male; mortality; multicenter study; observational study; outcome assessment; patient identification; prediction; prospective study; protein function; sepsis, Adult; Aged; Aged, 80 and over; Calcitonin; Clinical Laboratory Techniques; Female; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Protein Precursors; Sepsis; Treatment Outcome
