Τίτλος:
Whole blood interferon-γ release assay is a useful tool for the diagnosis of tuberculosis infection particularly among bacille calmette guèrin-vaccinated children
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The performance of QuantiFERON-tuberculosis (TB) Gold-In-Tube assay was compared with the tuberculin skin test for the diagnosis of TB among children. It was shown that among non-Bacille Calmette Guèrin immunized children, agreement between tests was excellent both in those with TB disease and in TB contacts. Among Bacille Calmette Guèrin-immunized children, agreement was fair in those with active disease and poor among TB contacts. It is concluded that QuantiFERON-TB Gold-In-Tube compares with the tuberculin skin test in the diagnosis of TB disease and latent tuberculosis infection in TB contacts among children and has enhanced specificity. © 2010 Lippincott Williams & Wilkins.
Συγγραφείς:
Tsolia, M.N.
Mavrikou, M.
Critselis, E.
Papadopoulos, N.G.
Makrinioti, H.
Spyridis, N.P.
Metsou, F.
Tsagaraki, M.
Koulouri, M.
Kafetzis, D.A.
Περιοδικό:
The Pediatric Infectious Disease Journal
Λέξεις-κλειδιά:
BCG vaccine; gamma interferon, article; BCG vaccination; child; controlled study; cytokine release; diagnostic test accuracy study; human; intermethod comparison; latent tuberculosis; major clinical study; pediatrics; priority journal; protein determination; sensitivity and specificity; skin test; tuberculin test; tuberculosis, Adolescent; BCG Vaccine; Blood; Cells, Cultured; Child; Child, Preschool; Diagnosis, Differential; Humans; Infant; Infant, Newborn; Interferon-gamma; Sensitivity and Specificity; Tuberculin Test; Tuberculosis
DOI:
10.1097/INF.0b013e3181ebfe8a
